published meta-analysis   sensitivity analysis   studies

anti-inflammatoty and immuno-therapy in COVID 19 hospitalized - Summary of results

OutcomeTE95% CInkI2ROBPub. bias death D28detailed resultsACTT-2 (Kalil), 2020 0.65 [0.39; 1.09] Aman, 2021 0.51 [0.27; 0.96] Bennett-Guerrero, 2021 0.86 [0.24; 3.11] CAN-COVID, 2020 0.67 [0.30; 1.50] CONTAIN COVID-19, 2021 0.86 [0.60; 1.25] COV-BARRIER, 2021 0.57 [0.41; 0.79] COV-BARRIER (critically ill), 2022 0.54 [0.31; 0.95] COVACTA (Rosas), 2020 1.02 [0.62; 1.68] Gharebaghi, 2020 0.00 [0.00; 0.09] ITAC, 2022 0.80 [0.42; 1.52] Kalil (ACTT-3), 2021 1.74 [0.51; 5.93] Lanzoni, 2021 0.14 [0.02; 0.96] Metcovid, 2020 0.92 [0.67; 1.28] NCT04377750 (HMO-0224-20), 0 0.48 [0.15; 1.55] NCT04412772 (ARCHITECTS), 0 0.18 [0.01; 3.72] O’Donnell, 2021 0.47 [0.21; 1.06] PLACO-COVID, 2021 1.71 [0.72; 4.06] PlasmAr, 2020 0.93 [0.47; 1.85] Rosas (REMDACTA), 2021 0.95 [0.65; 1.39] Shi, 2020 0.53 [0.01; 27.55] Singh (TD-0903 1mg), 2021 0.40 [0.03; 6.18] Singh (TD-0903 3mg), 2021 0.15 [0.01; 4.34] Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 0.61 [0.41; 0.92] STOP-COVID (Guimarães), 2021 0.49 [0.15; 1.62] Tang X, 2020 0.98 [0.93; 1.02] 0.75[0.63; 0.89]ACTT-2 (Kalil), 2020, Aman, 2021, Bennett-Guerrero, 2021, CAN-COVID, 2020, CONTAIN COVID-19, 2021, COV-BARRIER, 2021, COV-BARRIER (critically ill), 2022, COVACTA (Rosas), 2020, Gharebaghi, 2020, ITAC, 2022, Kalil (ACTT-3), 2021, Lanzoni, 2021, Metcovid, 2020, NCT04377750 (HMO-0224-20), 0, NCT04412772 (ARCHITECTS), 0, O’Donnell, 2021, PLACO-COVID, 2021, PlasmAr, 2020, Rosas (REMDACTA), 2021, Shi, 2020, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 2021, Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021, STOP-COVID (Guimarães), 2021, Tang X, 20202554%10,054moderatecritical death or transfer to ICUdetailed resultsBACC Bay Tocilizumab Trial, 2020 0.97 [0.50; 1.88] COLCHIVID, 2021 0.83 [0.35; 1.95] Lopardo, 2021 0.65 [0.35; 1.22] 0.80[0.53; 1.19]BACC Bay Tocilizumab Trial, 2020, COLCHIVID, 2021, Lopardo, 202130%483lownot evaluable deathsdetailed resultsACTIV-3/ TICO (sotrovimab), 2021 1.02 [0.48; 2.17] ACTIV-3/TICO (tixa), 2022 0.70 [0.50; 0.97] ACTIV-3/TICO LY-CoV555 , 2020 1.71 [0.56; 5.21] ACTT-2 (Kalil), 2020 0.65 [0.39; 1.09] Aman, 2021 0.51 [0.27; 0.96] BACC Bay Tocilizumab Trial, 2020 1.52 [0.41; 5.62] Baldeon, 2022 1.85 [0.49; 6.97] Bennett-Guerrero, 2021 0.80 [0.26; 2.45] CAN-COVID, 2020 0.67 [0.30; 1.50] CAPE-COVID, 2020 0.45 [0.20; 1.02] CCAP-2, 2021 2.03 [0.61; 6.77] COLCHIVID, 2021 0.69 [0.20; 2.40] CONTAIN COVID-19, 2021 0.86 [0.60; 1.25] COV-BARRIER, 2021 0.57 [0.41; 0.79] COV-BARRIER (critically ill), 2022 0.54 [0.31; 0.95] COVACTA (Rosas), 2020 1.16 [0.73; 1.84] CPC-SARS, 2021 0.04 [0.01; 0.26] DEVENT, 0 0.47 [0.22; 1.00] EMPACTA, 2020 1.13 [0.54; 2.40] Gharebaghi, 2020 0.00 [0.00; 0.09] ILBS-COVID-02 (Bajpai M), 2020 3.82 [0.35; 41.96] ITAC, 2022 0.80 [0.42; 1.52] Kalil (ACTT-3), 2021 1.74 [0.51; 5.93] LACCPT, 2021 1.17 [0.58; 2.36] Lanzoni, 2021 0.11 [0.01; 0.93] Lescure (Sarilumab 200mg), 2021 1.23 [0.49; 3.12] Lescure (Sarilumab 400mg), 2021 0.97 [0.38; 2.50] Libster, 2020 0.50 [0.09; 2.71] LIVE-AIR (Temesgen), 2021 0.70 [0.40; 1.21] Lopardo, 2021 0.57 [0.24; 1.37] Lopes MIF, 2020 1.06 [0.02; 56.61] Metcovid, 2020 0.92 [0.67; 1.28] NCT04377750 (HMO-0224-20), 0 0.48 [0.15; 1.55] NCT04412772 (ARCHITECTS), 0 0.18 [0.01; 3.72] NCT04442191, 2021 0.11 [0.00; 143.68] O’Donnell, 2021 0.47 [0.21; 1.06] PLACO-COVID, 2021 1.71 [0.72; 4.06] PlasmAr, 2020 0.93 [0.47; 1.85] Rosas (REMDACTA), 2021 0.95 [0.65; 1.39] Salehzadeh, 2020 1.00 [0.02; 51.41] sarilumab phase 2 high dose, 0 0.78 [0.34; 1.80] sarimulab phase 2 low dose, 0 1.51 [0.69; 3.32] SAVE-MORE, 2021 0.45 [0.20; 0.99] Shi, 2020 0.53 [0.01; 27.55] Singh (TD-0903 1mg), 2021 0.40 [0.03; 6.18] Singh (TD-0903 3mg), 2021 0.15 [0.01; 4.34] Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 0.61 [0.41; 0.92] SPRINTER, 2022 0.79 [0.38; 1.66] STOP-COVID (Guimarães), 2021 0.49 [0.15; 1.62] Synairgen SG016, 2020 0.16 [0.01; 3.31] Tang X, 2020 0.98 [0.93; 1.02] 0.78[0.68; 0.89]ACTIV-3/ TICO (sotrovimab), 2021, ACTIV-3/TICO (tixa), 2022, ACTIV-3/TICO LY-CoV555 , 2020, ACTT-2 (Kalil), 2020, Aman, 2021, BACC Bay Tocilizumab Trial, 2020, Baldeon, 2022, Bennett-Guerrero, 2021, CAN-COVID, 2020, CAPE-COVID, 2020, CCAP-2, 2021, COLCHIVID, 2021, CONTAIN COVID-19, 2021, COV-BARRIER, 2021, COV-BARRIER (critically ill), 2022, COVACTA (Rosas), 2020, CPC-SARS, 2021, DEVENT, 0, EMPACTA, 2020, Gharebaghi, 2020, ILBS-COVID-02 (Bajpai M), 2020, ITAC, 2022, Kalil (ACTT-3), 2021, LACCPT, 2021, Lanzoni, 2021, Lescure (Sarilumab 200mg), 2021, Lescure (Sarilumab 400mg), 2021, Libster, 2020, LIVE-AIR (Temesgen), 2021, Lopardo, 2021, Lopes MIF, 2020, Metcovid, 2020, NCT04377750 (HMO-0224-20), 0, NCT04412772 (ARCHITECTS), 0, NCT04442191, 2021, O’Donnell, 2021, PLACO-COVID, 2021, PlasmAr, 2020, Rosas (REMDACTA), 2021, Salehzadeh, 2020, sarilumab phase 2 high dose, 0, sarimulab phase 2 low dose, 0, SAVE-MORE, 2021, Shi, 2020, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 2021, Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021, SPRINTER, 2022, STOP-COVID (Guimarães), 2021, Synairgen SG016, 2020, Tang X, 20205145%16,570moderatecritical deaths (time to event analysis only)detailed resultsACTIV-3/ TICO (sotrovimab), 2021 1.02 [0.48; 2.17] ACTIV-3/TICO (tixa), 2022 0.70 [0.50; 0.97] ACTT-2 (Kalil), 2020 0.65 [0.39; 1.09] Baldeon, 2022 1.85 [0.49; 6.97] Bennett-Guerrero, 2021 0.80 [0.26; 2.45] COV-BARRIER, 2021 0.57 [0.41; 0.79] COVACTA (Rosas), 2020 1.16 [0.73; 1.84] Kalil (ACTT-3), 2021 1.74 [0.51; 5.93] Lanzoni, 2021 0.11 [0.01; 0.93] LIVE-AIR (Temesgen), 2021 0.70 [0.40; 1.21] PlasmAr, 2020 0.93 [0.47; 1.85] Rosas (REMDACTA), 2021 0.95 [0.65; 1.39] 0.80[0.65; 0.98]ACTIV-3/ TICO (sotrovimab), 2021, ACTIV-3/TICO (tixa), 2022, ACTT-2 (Kalil), 2020, Baldeon, 2022, Bennett-Guerrero, 2021, COV-BARRIER, 2021, COVACTA (Rosas), 2020, Kalil (ACTT-3), 2021, Lanzoni, 2021, LIVE-AIR (Temesgen), 2021, PlasmAr, 2020, Rosas (REMDACTA), 20211231%7,472moderatelow clinical deteriorationdetailed resultsBACC Bay Tocilizumab Trial, 2020 1.11 [0.59; 2.09] CONTAIN COVID-19, 2021 0.94 [0.75; 1.18] COV-BARRIER, 2021 1.12 [0.58; 2.16] EMPACTA, 2020 0.55 [0.33; 0.92] Libster, 2020 0.52 [0.29; 0.94] SAVE-MORE, 2021 0.36 [0.26; 0.50] SPRINTER, 2022 0.69 [0.43; 1.11] STOP-COVID (Guimarães), 2021 0.54 [0.27; 1.07] Synairgen SG016, 2020 0.50 [0.18; 1.38] Tang X, 2020 1.00 [0.13; 7.45] 0.66[0.49; 0.90]BACC Bay Tocilizumab Trial, 2020, CONTAIN COVID-19, 2021, COV-BARRIER, 2021, EMPACTA, 2020, Libster, 2020, SAVE-MORE, 2021, SPRINTER, 2022, STOP-COVID (Guimarães), 2021, Synairgen SG016, 2020, Tang X, 20201069%3,678lowlow clinical improvementdetailed resultsACTIV-3/TICO (tixa), 2022 1.08 [0.97; 1.20] ACTIV-3/TICO LY-CoV555 , 2020 0.85 [0.56; 1.29] ACTT-2 (Kalil), 2020 1.16 [1.01; 1.33] BACC Bay Tocilizumab Trial, 2020 1.06 [0.80; 1.41] Bennett-Guerrero, 2021 0.75 [0.21; 2.68] CAN-COVID, 2020 1.39 [0.76; 2.54] COV-BARRIER, 2021 1.25 [1.04; 1.50] COV-BARRIER (critically ill), 2022 2.87 [1.12; 7.36] COVACTA (Rosas), 2020 1.19 [0.81; 1.75] EMPACTA, 2020 1.15 [0.90; 1.47] ITAC, 2022 1.06 [0.77; 1.45] Kalil (ACTT-3), 2021 0.99 [0.87; 1.13] Lescure (Sarilumab 200mg), 2021 1.03 [0.75; 1.41] Lopardo, 2021 1.61 [0.75; 3.49] O’Donnell, 2021 1.20 [0.87; 1.65] PlasmAr, 2020 0.81 [0.50; 1.31] sarilumab phase 2 high dose, 0 2.09 [1.00; 4.36] sarimulab phase 2 low dose, 0 1.51 [0.73; 3.11] Singh (TD-0903 1mg), 2021 2.50 [0.16; 38.60] Singh (TD-0903 3mg), 2021 3.00 [0.20; 45.25] Synairgen SG016, 2020 2.32 [1.07; 5.04] Tang X, 2020 1.04 [0.67; 1.62] 1.11[1.04; 1.19]ACTIV-3/TICO (tixa), 2022, ACTIV-3/TICO LY-CoV555 , 2020, ACTT-2 (Kalil), 2020, BACC Bay Tocilizumab Trial, 2020, Bennett-Guerrero, 2021, CAN-COVID, 2020, COV-BARRIER, 2021, COV-BARRIER (critically ill), 2022, COVACTA (Rosas), 2020, EMPACTA, 2020, ITAC, 2022, Kalil (ACTT-3), 2021, Lescure (Sarilumab 200mg), 2021, Lopardo, 2021, O’Donnell, 2021, PlasmAr, 2020, sarilumab phase 2 high dose, 0, sarimulab phase 2 low dose, 0, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 2021, Synairgen SG016, 2020, Tang X, 2020229%8,569moderatecritical clinical improvement (14-day)detailed resultsACTT-2 (Kalil), 2020 1.30 [1.03; 1.64] COV-BARRIER, 2021 1.28 [1.05; 1.56] COV-BARRIER (critically ill), 2022 1.97 [0.95; 4.09] Kalil (ACTT-3), 2021 1.01 [0.79; 1.29] Tang X, 2020 1.33 [0.57; 3.11] 1.22[1.07; 1.41]ACTT-2 (Kalil), 2020, COV-BARRIER, 2021, COV-BARRIER (critically ill), 2022, Kalil (ACTT-3), 2021, Tang X, 2020512%3,714lownot evaluable clinical improvement (28-day)detailed resultsBennett-Guerrero, 2021 1.02 [0.25; 4.20] COV-BARRIER (critically ill), 2022 1.82 [0.87; 3.81] COVACTA (Rosas), 2020 1.19 [0.81; 1.75] O’Donnell, 2021 1.38 [0.73; 2.61] Singh (TD-0903 1mg), 2021 2.50 [0.16; 38.60] Singh (TD-0903 3mg), 2021 3.00 [0.20; 45.25] Synairgen SG016, 2020 3.15 [1.39; 7.14] 1.47[1.11; 1.93]Bennett-Guerrero, 2021, COV-BARRIER (critically ill), 2022, COVACTA (Rosas), 2020, O’Donnell, 2021, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 2021, Synairgen SG016, 202070%962moderatenot evaluable clinical improvement (7-day)detailed resultsACTIV-3/TICO LY-CoV555 , 2020 0.85 [0.56; 1.29] ITAC, 2022 1.06 [0.77; 1.45] 0.98[0.76; 1.26]ACTIV-3/TICO LY-CoV555 , 2020, ITAC, 202220%899moderatenot evaluable clinical improvement (time to event analysis only)detailed resultsACTT-2 (Kalil), 2020 1.16 [1.01; 1.33] Bennett-Guerrero, 2021 0.75 [0.21; 2.68] EMPACTA, 2020 1.15 [0.90; 1.47] Kalil (ACTT-3), 2021 0.99 [0.87; 1.13] Lescure (Sarilumab 200mg), 2021 1.03 [0.75; 1.41] Lescure (Sarilumab 400mg), 2021 1.14 [0.84; 1.54] O’Donnell, 2021 1.20 [0.87; 1.65] PlasmAr, 2020 1.00 [0.76; 1.32] sarimulab phase 2 low dose, 0 0.96 [0.53; 1.73] SPRINTER, 2022 1.02 [0.81; 1.28] Tang X, 2020 1.04 [0.67; 1.62] 1.07[1.00; 1.15]ACTT-2 (Kalil), 2020, Bennett-Guerrero, 2021, EMPACTA, 2020, Kalil (ACTT-3), 2021, Lescure (Sarilumab 200mg), 2021, Lescure (Sarilumab 400mg), 2021, O’Donnell, 2021, PlasmAr, 2020, sarimulab phase 2 low dose, 0, SPRINTER, 2022, Tang X, 2020110%4,095lowlow death or ventilationdetailed resultsACTT-2 (Kalil), 2020 0.69 [0.50; 0.95] BACC Bay Tocilizumab Trial, 2020 0.83 [0.38; 1.81] CAPE-COVID, 2020 0.71 [0.37; 1.35] EMPACTA, 2020 0.56 [0.32; 0.97] LIVE-AIR (Temesgen), 2021 0.65 [0.43; 0.98] Rosas (REMDACTA), 2021 0.98 [0.72; 1.34] sarilumab phase 2 high dose, 0 0.39 [0.18; 0.82] sarimulab phase 2 low dose, 0 0.70 [0.34; 1.44] Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 0.66 [0.46; 0.94] SPRINTER, 2022 0.85 [0.45; 1.61] STOP-COVID (Guimarães), 2021 0.63 [0.41; 0.97] Synairgen SG016, 2020 0.38 [0.09; 1.63] 0.71[0.62; 0.81]ACTT-2 (Kalil), 2020, BACC Bay Tocilizumab Trial, 2020, CAPE-COVID, 2020, EMPACTA, 2020, LIVE-AIR (Temesgen), 2021, Rosas (REMDACTA), 2021, sarilumab phase 2 high dose, 0, sarimulab phase 2 low dose, 0, Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021, SPRINTER, 2022, STOP-COVID (Guimarães), 2021, Synairgen SG016, 2020120%4,452moderatelow hospital dischargedetailed resultsACTIV-3/TICO LY-CoV555 , 2020 0.97 [0.78; 1.20] CAPE-COVID, 2020 1.67 [0.87; 3.19] COLCHIVID, 2021 1.13 [0.76; 1.67] EMPACTA, 2020 1.16 [0.90; 1.49] Rosas (REMDACTA), 2021 0.97 [0.79; 1.20] Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 1.48 [1.05; 2.09] SPRINTER, 2022 1.06 [0.89; 1.27] Synairgen SG016, 2020 1.63 [0.61; 4.35] 1.09[0.98; 1.21]ACTIV-3/TICO LY-CoV555 , 2020, CAPE-COVID, 2020, COLCHIVID, 2021, EMPACTA, 2020, Rosas (REMDACTA), 2021, Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021, SPRINTER, 2022, Synairgen SG016, 2020812%3,159lowserious hospitalizationdetailed resultsJagannathan, 2020 1.00 [0.14; 7.34] 1.00[0.14; 7.34]Jagannathan, 202010%120NAnot evaluable mechanical ventilationdetailed resultsACTT-2 (Kalil), 2020 0.64 [0.44; 0.93] CAPE-COVID, 2020 0.95 [0.44; 2.04] COVACTA (Rosas), 2020 0.67 [0.39; 1.14] Metcovid, 2020 1.19 [0.56; 2.49] O’Donnell, 2021 1.50 [0.47; 4.82] PlasmAr, 2020 0.86 [0.39; 1.93] sarilumab phase 2 high dose, 0 0.27 [0.10; 0.71] sarimulab phase 2 low dose, 0 0.28 [0.11; 0.73] SAVE-MORE, 2021 0.47 [0.03; 7.48] Singh (TD-0903 1mg), 2021 0.09 [0.00; 2.48] Singh (TD-0903 3mg), 2021 0.08 [0.00; 2.07] 0.66[0.48; 0.91]ACTT-2 (Kalil), 2020, CAPE-COVID, 2020, COVACTA (Rosas), 2020, Metcovid, 2020, O’Donnell, 2021, PlasmAr, 2020, sarilumab phase 2 high dose, 0, sarimulab phase 2 low dose, 0, SAVE-MORE, 2021, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 20211133%3,088moderatelow Recovery (time to event analysis only)detailed resultsSPRINTER, 2022 1.02 [0.81; 1.28] 1.02[0.81; 1.28]SPRINTER, 202210%623NAnot evaluable viral clearance detailed resultsJagannathan, 2020 0.81 [0.56; 1.18] Tang X, 2020 1.78 [1.06; 3.00] 1.18[0.54; 2.54]Jagannathan, 2020, Tang X, 2020283%206moderatenot evaluable viral clearance (time to event analysis only)detailed resultsJagannathan, 2020 0.81 [0.56; 1.18] Tang X, 2020 1.78 [1.06; 3.00] 1.18[0.54; 2.54]Jagannathan, 2020, Tang X, 2020283%206moderatenot evaluable ICU admissiondetailed resultsCOVACTA (Rosas), 2020 0.48 [0.25; 0.94] Libster, 2020 0.33 [0.07; 1.58] Lopardo, 2021 0.67 [0.35; 1.28] Lopes MIF, 2020 1.06 [0.06; 18.45] Tang X, 2020 1.00 [0.13; 7.45] 0.57[0.37; 0.87]COVACTA (Rosas), 2020, Libster, 2020, Lopardo, 2021, Lopes MIF, 2020, Tang X, 202050%713moderatenot evaluable off oxygenationdetailed resultsILBS-COVID-02 (Bajpai M), 2020 0.26 [0.02; 2.88] sarilumab phase 2 high dose, 0 1.99 [0.95; 4.15] sarimulab phase 2 low dose, 0 1.07 [0.52; 2.21] 1.27[0.62; 2.60]ILBS-COVID-02 (Bajpai M), 2020, sarilumab phase 2 high dose, 0, sarimulab phase 2 low dose, 0339%299seriousnot evaluable recoverydetailed resultsACTIV-3 (BRII-196 and BRII-198), 2021 1.08 [0.88; 1.32] ACTIV-3/ TICO (sotrovimab), 2021 1.12 [0.91; 1.37] ACTIV-3/TICO LY-CoV555 , 2020 1.06 [0.77; 1.46] COV-BARRIER (critically ill), 2022 1.57 [0.77; 3.20] Lanzoni, 2021 3.46 [1.05; 11.35] Synairgen SG016, 2020 2.19 [1.03; 4.67] 1.19[0.99; 1.42]ACTIV-3 (BRII-196 and BRII-198), 2021, ACTIV-3/ TICO (sotrovimab), 2021, ACTIV-3/TICO LY-CoV555 , 2020, COV-BARRIER (critically ill), 2022, Lanzoni, 2021, Synairgen SG016, 2020633%1,254lowserious composite safety outcome detailed resultsACTIV-3/TICO LY-CoV555 , 2020 1.56 [0.78; 3.11] 1.56[0.78; 3.11]ACTIV-3/TICO LY-CoV555 , 202010%314NAnot evaluable related AE (TRAE)detailed resultsSingh (TD-0903 1mg), 2021 2.50 [0.16; 38.60] Singh (TD-0903 3mg), 2021 0.38 [0.01; 13.93] 1.26[0.14; 11.07]Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 202120%25moderatenot evaluable serious adverse eventsdetailed resultsBACC Bay Tocilizumab Trial, 2020 1.21 [0.58; 2.53] CAN-COVID, 2020 0.73 [0.45; 1.19] COVACTA (Rosas), 2020 0.81 [0.54; 1.22] ITAC, 2022 0.98 [0.66; 1.46] Jagannathan, 2020 1.00 [0.14; 7.34] Lanzoni, 2021 0.10 [0.01; 0.69] Lescure (Sarilumab 200mg), 2021 1.15 [0.62; 2.12] Lescure (Sarilumab 400mg), 2021 1.38 [0.76; 2.51] O’Donnell, 2021 0.64 [0.35; 1.17] PlasmAr, 2020 1.40 [0.78; 2.51] Rosas (REMDACTA), 2021 0.83 [0.59; 1.18] Shi, 2020 1.08 [0.04; 32.96] 0.92[0.77; 1.10]BACC Bay Tocilizumab Trial, 2020, CAN-COVID, 2020, COVACTA (Rosas), 2020, ITAC, 2022, Jagannathan, 2020, Lanzoni, 2021, Lescure (Sarilumab 200mg), 2021, Lescure (Sarilumab 400mg), 2021, O’Donnell, 2021, PlasmAr, 2020, Rosas (REMDACTA), 2021, Shi, 20201215%3,647moderatelow superinfectiondetailed resultsACTT-2 (Kalil), 2020 0.50 [0.32; 0.79] CAPE-COVID, 2020 0.81 [0.49; 1.34] Metcovid, 2020 0.98 [0.65; 1.47] 0.74[0.49; 1.11]ACTT-2 (Kalil), 2020, CAPE-COVID, 2020, Metcovid, 2020357%1,575lownot evaluable adverse eventsdetailed resultsCOLCHIVID, 2021 1.63 [0.67; 3.95] COVACTA (Rosas), 2020 0.87 [0.52; 1.45] Jagannathan, 2020 1.33 [0.63; 2.78] Lanzoni, 2021 0.18 [0.02; 1.95] Lescure (Sarilumab 200mg), 2021 0.97 [0.56; 1.69] Lescure (Sarilumab 400mg), 2021 1.31 [0.76; 2.27] Rosas (REMDACTA), 2021 1.32 [0.92; 1.89] Shi, 2020 0.88 [0.38; 2.03] Singh (TD-0903 1mg), 2021 0.45 [0.01; 16.71] Singh (TD-0903 3mg), 2021 0.04 [0.00; 1.01] 1.11[0.88; 1.40]COLCHIVID, 2021, COVACTA (Rosas), 2020, Jagannathan, 2020, Lanzoni, 2021, Lescure (Sarilumab 200mg), 2021, Lescure (Sarilumab 400mg), 2021, Rosas (REMDACTA), 2021, Shi, 2020, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 20211011%1,851moderatecritical0.25.01.0relative treatment effectwww.metaEvidence.org2024-06-05 11:27 +02:00

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;

pathologies: 95,94,90,91 - treatments: 546,564,944,682,1266,943,894,560,1102,598,563,668,753,752,836,639,541,534,581,615,679,522,582,666,1149,1150,737,544,733,597,524,611,538,957,958,521,566,517,881,904,882,897,896,899,1235,898,687,740,883,947,536,591,729,887,742,878,975,570,771,888,1141,690,880,1255,567,596,1437,600,652,557,635,1236,553,628,646,645,607,395,920,1438,927,932,931,1263,599,614,942,1436,928,923,535,1046,727,818,606,954,964,962,963,1045,638,677,627,533,526,616,926,1246,726,580,568,527,588,539,585,691,1210,525 - roots T: 290