Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament Trials      
clinical improvementclinical worseningdeathsPCR-negative conversion
Immunosuppressants drugs13 1.37 [1.01; 1.87], 3 RCTs, I2=0%
low degree of certainty
- 1.10 [0.58; 2.10], 2 RCTs, I2=21%
inconclusive result
-
corticosteroids11- OBS 1.74 [0.14; 22.23], 2 studies, I2=86%
inconclusive result
0.83 [0.74; 0.93], 1 RCT, I2=0% demonstrated
moderate degree of certainty
-
Immunostimulants drugs11 1.40 [0.79; 2.49], 1 RCT, I2=0%
inconclusive result
- 0.58 [0.30; 1.11], 2 RCTs, I2=0%
inconclusive result
-
anti-inflammatory therapies1-- OBS 0.41 [0.19; 0.89], 1 study, I2=0%
very low degree of certainty
-
Apilimod0----
imatinib0----
leflunomide0----
pirfenidone0----
Polyinosinic-Polycytidylic Acid0----
sargramostim0----
thymosin0----