published meta-analysis   sensitivity analysis   studies

anti-inflammatoty and immuno-therapy in COVID 19 hospitalized - Summary of results

OutcomeTE95% CInkI2ROBPub. bias 14-days deathsdetailed resultsConPlas-19, 2020 0.56 [0.20; 1.57] DAWN-Plasma, 2021 0.61 [0.24; 1.55] NCT04397757, 2021 0.47 [0.04; 5.45] Sekine (PLACOVID), 2021 2.14 [0.70; 6.58] 0.82[0.42; 1.61]ConPlas-19, 2020, DAWN-Plasma, 2021, NCT04397757, 2021, Sekine (PLACOVID), 2021424%1,072moderatenot evaluable death D28detailed resultsACTT-2 (Kalil), 2020 0.65 [0.39; 1.09] AlQahtani, 2020 0.47 [0.04; 5.69] Aman, 2021 0.51 [0.27; 0.96] Amra, 2021 0.47 [0.12; 1.93] ASCOT, 2021 0.60 [0.06; 5.99] Balcells, 2020 4.22 [0.33; 53.77] Bennett-Guerrero, 2021 0.86 [0.24; 3.11] CAN-COVID, 2020 0.67 [0.30; 1.50] Co-CLARITY, 2021 0.92 [0.02; 50.28] COL-COVID (Pascual-Figal), 2021 0.24 [0.01; 5.41] COLCOVID, 2021 0.88 [0.70; 1.11] CONCOR-1, 2021 1.12 [0.86; 1.46] ConPlas-19, 2020 0.49 [0.20; 1.19] CONTAIN COVID-19, 2021 0.86 [0.60; 1.25] COPLA-II trial, 2020 1.17 [0.72; 1.92] CORIMUNO-ANA-1, 2021 0.91 [0.38; 2.19] CORIMUNO-SARI-1 (non ICU), 2021 0.59 [0.23; 1.51] CORIMUNO-TOCI-ICU (Group 2), 2020 0.64 [0.23; 1.80] COV-BARRIER, 2021 0.57 [0.41; 0.79] COV-BARRIER (critically ill), 2022 0.54 [0.31; 0.95] COVACTA (Rosas), 2020 1.02 [0.62; 1.68] Davoudi-Monfared, 2020 0.30 [0.11; 0.83] DAWN-Plasma, 2021 0.99 [0.52; 1.88] Declercq J (COV-AID), 2021 1.02 [0.39; 2.66] EU-CTR2020-001375-32 (PreToVid), 0 0.59 [0.33; 1.06] EU-CTR2020-001748-24 (ImmCoVA), 0 1.25 [0.16; 9.72] Gaitan-Duarte (Rosuvastatin plus colchicine), 2021 0.81 [0.48; 1.36] Gharebaghi, 2020 0.00 [0.00; 0.09] GLUCOCOVID, 2020 0.63 [0.25; 1.60] Horby, 2021 1.01 [0.93; 1.10] ITAC, 2022 0.80 [0.42; 1.52] Jamaati, 2021 1.19 [0.38; 3.72] Kalil (ACTT-3), 2021 1.74 [0.51; 5.93] Kirenga, 2021 1.25 [0.46; 3.39] Lanzoni, 2021 0.14 [0.02; 0.96] Li, 2020 0.59 [0.22; 1.59] LIFESAVER, 2021 2.00 [0.16; 24.66] MARIPOSA, 2021 1.43 [0.42; 4.87] Menichetti, 2021 0.75 [0.37; 1.53] Metcovid, 2020 0.92 [0.67; 1.28] NCT04377750 (HMO-0224-20), 0 0.48 [0.15; 1.55] NCT04397757, 2021 0.15 [0.03; 0.75] NCT04403477 (two doses), 2021 0.53 [0.14; 2.01] NCT04412772 (ARCHITECTS), 0 0.18 [0.01; 3.72] NCT04434717 (COVITOZ-1 single dose plus two doses), 0 0.52 [0.01; 28.31] NCT04479358 (COVIDOSE-2 substudy A 120mg plus 40mg), 0 0.07 [0.01; 0.88] NCT04528368, 2021 0.88 [0.02; 50.20] NCT04577534 (COVIDSTORM), 0 0.49 [0.01; 26.18] O’Donnell, 2021 0.47 [0.21; 1.06] Pandit, 2021 0.95 [0.02; 50.33] PC/COVID-19, 2021 0.63 [0.11; 3.58] PERUCONPLASMA, 2021 0.36 [0.04; 3.13] PICP19 (Ray), 2020 0.67 [0.30; 1.51] PLACID, 2020 1.04 [0.66; 1.63] PLACO-COVID, 2021 1.71 [0.72; 4.06] PlasmAr, 2020 0.93 [0.47; 1.85] Pouladzadeh, 2021 0.31 [0.01; 10.20] Raman, 2021 0.49 [0.02; 15.10] Rashad, 2021 0.35 [0.17; 0.74] Rashad, 2021 2.86 [1.36; 6.01] RECOVER, 2021 1.09 [0.38; 3.13] RECOVERY, 2022 0.87 [0.77; 0.98] RECOVERY (colchicine), 2021 1.01 [0.93; 1.10] RECOVERY (plasma), 2021 1.00 [0.93; 1.07] RECOVERY (REGN-COV2), 2021 0.80 [0.70; 0.91] REMAP-CAP, fixed 7-day course, 2020 1.03 [0.54; 1.98] REMAP-CAP, shock-dependent course, 2020 1.10 [0.58; 2.10] Rosas (REMDACTA), 2021 0.95 [0.65; 1.39] Rutgers, 2021 0.59 [0.33; 1.06] Sakoulas, 2020 0.29 [0.03; 3.13] Sekine (PLACOVID), 2021 1.38 [0.73; 2.62] Shashi Bhushan, 2021 4.39 [0.20; 98.33] Shi, 2020 0.53 [0.01; 27.55] Shu, 2020 0.38 [0.02; 8.14] Singh (TD-0903 1mg), 2021 0.40 [0.03; 6.18] Singh (TD-0903 3mg), 2021 0.15 [0.01; 4.34] Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 0.61 [0.41; 0.92] STOP-COVID (Guimarães), 2021 0.49 [0.15; 1.62] Tabarsi, 2020 1.10 [0.45; 2.67] Talaschian, 2021 1.56 [0.34; 7.13] Tang X, 2020 0.98 [0.93; 1.02] TOCOVID, 0 0.99 [0.02; 50.02] Veiga, 2021 2.70 [0.92; 7.92] 0.88[0.82; 0.94]ACTT-2 (Kalil), 2020, AlQahtani, 2020, Aman, 2021, Amra, 2021, ASCOT, 2021, Balcells, 2020, Bennett-Guerrero, 2021, CAN-COVID, 2020, Co-CLARITY, 2021, COL-COVID (Pascual-Figal), 2021, COLCOVID, 2021, CONCOR-1, 2021, ConPlas-19, 2020, CONTAIN COVID-19, 2021, COPLA-II trial, 2020, CORIMUNO-ANA-1, 2021, CORIMUNO-SARI-1 (non ICU), 2021, CORIMUNO-TOCI-ICU (Group 2), 2020, COV-BARRIER, 2021, COV-BARRIER (critically ill), 2022, COVACTA (Rosas), 2020, Davoudi-Monfared, 2020, DAWN-Plasma, 2021, Declercq J (COV-AID), 2021, EU-CTR2020-001375-32 (PreToVid), 0, EU-CTR2020-001748-24 (ImmCoVA), 0, Gaitan-Duarte (Rosuvastatin plus colchicine), 2021, Gharebaghi, 2020, GLUCOCOVID, 2020, Horby, 2021, ITAC, 2022, Jamaati, 2021, Kalil (ACTT-3), 2021, Kirenga, 2021, Lanzoni, 2021, Li, 2020, LIFESAVER, 2021, MARIPOSA, 2021, Menichetti, 2021, Metcovid, 2020, NCT04377750 (HMO-0224-20), 0, NCT04397757, 2021, NCT04403477 (two doses), 2021, NCT04412772 (ARCHITECTS), 0, NCT04434717 (COVITOZ-1 single dose plus two doses), 0, NCT04479358 (COVIDOSE-2 substudy A 120mg plus 40mg), 0, NCT04528368, 2021, NCT04577534 (COVIDSTORM), 0, O’Donnell, 2021, Pandit, 2021, PC/COVID-19, 2021, PERUCONPLASMA, 2021, PICP19 (Ray), 2020, PLACID, 2020, PLACO-COVID, 2021, PlasmAr, 2020, Pouladzadeh, 2021, Raman, 2021, Rashad, 2021, Rashad, 2021, RECOVER, 2021, RECOVERY, 2022, RECOVERY (colchicine), 2021, RECOVERY (plasma), 2021, RECOVERY (REGN-COV2), 2021, REMAP-CAP, fixed 7-day course, 2020, REMAP-CAP, shock-dependent course, 2020, Rosas (REMDACTA), 2021, Rutgers, 2021, Sakoulas, 2020, Sekine (PLACOVID), 2021, Shashi Bhushan, 2021, Shi, 2020, Shu, 2020, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 2021, Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021, STOP-COVID (Guimarães), 2021, Tabarsi, 2020, Talaschian, 2021, Tang X, 2020, TOCOVID, 0, Veiga, 20218335%64,890moderatecritical death or transfer to ICUdetailed resultsBACC Bay Tocilizumab Trial, 2020 0.97 [0.50; 1.88] COLCHIVID, 2021 0.83 [0.35; 1.95] GLUCOCOVID, 2020 0.68 [0.37; 1.25] Lopardo, 2021 0.65 [0.35; 1.22] PLACID, 2020 1.07 [0.73; 1.57] 0.88[0.68; 1.13]BACC Bay Tocilizumab Trial, 2020, COLCHIVID, 2021, GLUCOCOVID, 2020, Lopardo, 2021, PLACID, 202050%1,010moderatenot evaluable deathsdetailed resultsACTIV-3/ TICO (sotrovimab), 2021 1.02 [0.48; 2.17] ACTIV-3/TICO (tixa), 2022 0.70 [0.50; 0.97] ACTIV-3/TICO LY-CoV555 , 2020 1.71 [0.56; 5.21] ACTT-2 (Kalil), 2020 0.65 [0.39; 1.09] AlQahtani, 2020 0.47 [0.04; 5.69] Aman, 2021 0.51 [0.27; 0.96] ASCOT, 2021 0.60 [0.06; 5.99] BACC Bay Tocilizumab Trial, 2020 1.52 [0.41; 5.62] Balcells, 2020 3.26 [0.62; 17.12] Baldeon, 2022 1.85 [0.49; 6.97] Bennett-Guerrero, 2021 0.80 [0.26; 2.45] CAN-COVID, 2020 0.67 [0.30; 1.50] Cao, 2020 0.15 [0.01; 3.29] CAPE-COVID, 2020 0.45 [0.20; 1.02] CAPSID, 2021 0.84 [0.28; 2.50] CCAP-2, 2021 2.03 [0.61; 6.77] Co-CLARITY, 2021 0.92 [0.02; 50.28] CODEX (Tomazini), 2020 0.97 [0.72; 1.31] COL-COVID (Pascual-Figal), 2021 0.24 [0.01; 5.41] COLCHIVID, 2021 0.69 [0.20; 2.40] COLCOVID, 2021 0.88 [0.70; 1.11] CONCOR-1, 2021 1.02 [0.77; 1.36] ConCOVID (Gharbharan et al.), 2020 0.95 [0.20; 4.59] CONFIDENT, 2020 0.84 [0.52; 1.37] ConPlas-19, 2020 0.46 [0.19; 1.15] CONTAIN COVID-19, 2021 0.86 [0.60; 1.25] COP-COVID-19, 2021 0.96 [0.36; 2.56] COPLA-II trial, 2020 1.17 [0.72; 1.92] CORIMUNO-ANA-1, 2021 0.97 [0.46; 2.04] CORIMUNO-SARI-1 (non ICU), 2021 0.59 [0.23; 1.51] CORIMUNO-TOCI-1 (Group 1), 2020 0.92 [0.31; 2.71] CORIMUNO-TOCI-ICU (Group 2), 2020 0.64 [0.23; 1.80] COV-BARRIER, 2021 0.57 [0.41; 0.79] COV-BARRIER (critically ill), 2022 0.54 [0.31; 0.95] COVACTA (Rosas), 2020 1.16 [0.73; 1.84] CP-COVID-19, 2021 3.20 [0.62; 16.39] CPC-SARS, 2021 0.04 [0.01; 0.26] Darazam, 2021 1.21 [0.65; 2.25] Darazam (COVIFERON Interferon beta-1a), 2021 0.31 [0.07; 1.25] Darazam (COVIFERON Interferon beta-1b), 2021 0.52 [0.14; 1.92] Davoudi-Monfared, 2020 0.38 [0.16; 0.87] DAWN-Plasma, 2021 0.99 [0.52; 1.88] Declercq J (COV-AID), 2021 1.02 [0.39; 2.66] DEVENT, 0 0.47 [0.22; 1.00] DEXA-COVID19, 2020 2.00 [0.21; 18.87] Edalatifard, 2020 0.29 [0.15; 0.56] EMPACTA, 2020 1.13 [0.54; 2.40] Esquivel-Moynelo, 2020 1.10 [0.02; 57.31] EU-CTR2020-001375-32 (PreToVid), 0 0.59 [0.33; 1.06] EU-CTR2020-001748-24 (ImmCoVA), 0 1.25 [0.16; 9.72] Fu, 2020 1.00 [0.02; 51.66] Gaitan-Duarte (Rosuvastatin plus colchicine), 2021 0.81 [0.48; 1.36] Gharebaghi, 2020 0.00 [0.00; 0.09] GLUCOCOVID, 2020 0.63 [0.25; 1.60] GRECCO-19, 2020 0.21 [0.02; 1.97] Hamed, 2021 1.83 [0.16; 21.66] Holm K, 2021 0.49 [0.08; 2.89] Horby, 2021 1.01 [0.93; 1.10] ILBS-COVID-02 (Bajpai M), 2020 3.82 [0.35; 41.96] ITAC, 2022 0.80 [0.42; 1.52] Jamaati, 2021 1.19 [0.38; 3.72] Kalil (ACTT-3), 2021 1.74 [0.51; 5.93] Kirenga, 2021 1.25 [0.46; 3.39] Kumar, 2021 0.06 [0.00; 1.35] LACCPT, 2021 1.17 [0.58; 2.36] Lanzoni, 2021 0.11 [0.01; 0.93] Lescure (Sarilumab 200mg), 2021 1.23 [0.49; 3.12] Lescure (Sarilumab 400mg), 2021 0.97 [0.38; 2.50] Li, 2020 0.59 [0.22; 1.59] Li, 2021 1.04 [0.02; 53.73] Libster, 2020 0.50 [0.09; 2.71] LIFESAVER, 2021 2.00 [0.16; 24.66] LIVE-AIR (Temesgen), 2021 0.70 [0.40; 1.21] Lopardo, 2021 0.57 [0.24; 1.37] Lopes MIF, 2020 1.06 [0.02; 56.61] Menichetti, 2021 0.75 [0.37; 1.53] Metcovid, 2020 0.92 [0.67; 1.28] Murugesan, 2022 1.00 [0.02; 51.41] NCT04377750 (HMO-0224-20), 0 0.48 [0.15; 1.55] NCT04385199, 2021 0.75 [0.15; 3.77] NCT04397757, 2021 0.15 [0.03; 0.75] NCT04403477 (two doses), 2021 0.53 [0.14; 2.01] NCT04412772 (ARCHITECTS), 0 0.18 [0.01; 3.72] NCT04434717 (COVITOZ-1 single dose plus two doses), 0 0.52 [0.01; 28.31] NCT04442191, 2021 0.11 [0.00; 143.68] NCT04479358 (COVIDOSE-2 substudy A 120mg plus 40mg), 0 0.07 [0.01; 0.88] NCT04528368, 2021 0.88 [0.02; 50.20] NCT04577534 (COVIDSTORM), 0 0.49 [0.01; 26.18] O’Donnell, 2021 0.47 [0.21; 1.06] Pandit, 2021 0.95 [0.02; 50.33] PC/COVID-19, 2021 0.63 [0.11; 3.58] PERUCONPLASMA, 2021 0.36 [0.04; 3.13] PICP19 (Ray), 2020 0.67 [0.30; 1.51] PLACID, 2020 1.04 [0.66; 1.63] PLACO-COVID, 2021 1.71 [0.72; 4.06] PlasmAr, 2020 0.93 [0.47; 1.85] Pouladzadeh, 2021 0.31 [0.01; 10.20] Rahmani, 2020 0.29 [0.05; 1.56] Raman, 2021 0.49 [0.02; 15.10] Ranjbar, 2021 0.40 [0.15; 1.08] Rashad, 2021 2.16 [1.14; 4.09] Rashad, 2021 0.46 [0.24; 0.88] Rasheed, 2020 0.13 [0.01; 1.09] RCT-TCZ-COVID-19, 2021 2.24 [0.20; 25.37] RECOVER, 2021 1.09 [0.38; 3.13] RECOVERY, 2021 0.85 [0.76; 0.95] RECOVERY, 2022 0.87 [0.77; 0.98] RECOVERY (colchicine), 2021 1.01 [0.93; 1.10] RECOVERY (plasma), 2021 1.00 [0.93; 1.07] RECOVERY (REGN-COV2), 2021 0.80 [0.70; 0.91] RECOVERY dexamethasone, 2020 0.83 [0.75; 0.92] REMAP-CAP (plasma), 2021 0.96 [0.80; 1.15] REMAP-CAP (tocilizumab), 2021 0.70 [0.51; 0.95] REMAP-CAP sarilumab, 2021 0.51 [0.25; 1.07] REMAP-CAP, fixed 7-day course, 2020 0.94 [0.61; 1.45] REMAP-CAP, shock-dependent course, 2020 0.98 [0.63; 1.53] Rosas (REMDACTA), 2021 0.95 [0.65; 1.39] Rutgers, 2021 0.62 [0.36; 1.07] Sakoulas, 2020 0.29 [0.03; 3.13] Salehzadeh, 2020 1.00 [0.02; 51.41] sarilumab phase 2 high dose, 0 0.78 [0.34; 1.80] sarimulab phase 2 low dose, 0 1.51 [0.69; 3.32] SAVE-MORE, 2021 0.45 [0.20; 0.99] Sekine (PLACOVID), 2021 1.38 [0.73; 2.62] Shashi Bhushan, 2021 4.39 [0.20; 98.33] Shi, 2020 0.53 [0.01; 27.55] Shu, 2020 0.38 [0.02; 8.14] Singh (TD-0903 1mg), 2021 0.40 [0.03; 6.18] Singh (TD-0903 3mg), 2021 0.15 [0.01; 4.34] Soin AS (COVINTOC), 2021 0.67 [0.29; 1.55] SOLIDARITY (interferon), 2020 1.16 [0.96; 1.40] Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 0.61 [0.41; 0.92] SPRINTER, 2022 0.79 [0.38; 1.66] Steroids-SARI, 2020 0.91 [0.29; 2.86] STOP-COVID (Guimarães), 2021 0.49 [0.15; 1.62] Synairgen SG016, 2020 0.16 [0.01; 3.31] Tabarsi, 2020 1.10 [0.45; 2.67] Talaschian, 2021 1.25 [0.30; 5.14] Tang X, 2020 0.98 [0.93; 1.02] TOCOVID, 0 0.99 [0.02; 50.02] Veiga, 2021 2.70 [0.92; 7.92] Wang, 2020 1.00 [0.02; 52.54] 0.86[0.81; 0.91]ACTIV-3/ TICO (sotrovimab), 2021, ACTIV-3/TICO (tixa), 2022, ACTIV-3/TICO LY-CoV555 , 2020, ACTT-2 (Kalil), 2020, AlQahtani, 2020, Aman, 2021, ASCOT, 2021, BACC Bay Tocilizumab Trial, 2020, Balcells, 2020, Baldeon, 2022, Bennett-Guerrero, 2021, CAN-COVID, 2020, Cao, 2020, CAPE-COVID, 2020, CAPSID, 2021, CCAP-2, 2021, Co-CLARITY, 2021, CODEX (Tomazini), 2020, COL-COVID (Pascual-Figal), 2021, COLCHIVID, 2021, COLCOVID, 2021, CONCOR-1, 2021, ConCOVID (Gharbharan et al.), 2020, CONFIDENT, 2020, ConPlas-19, 2020, CONTAIN COVID-19, 2021, COP-COVID-19, 2021, COPLA-II trial, 2020, CORIMUNO-ANA-1, 2021, CORIMUNO-SARI-1 (non ICU), 2021, CORIMUNO-TOCI-1 (Group 1), 2020, CORIMUNO-TOCI-ICU (Group 2), 2020, COV-BARRIER, 2021, COV-BARRIER (critically ill), 2022, COVACTA (Rosas), 2020, CP-COVID-19, 2021, CPC-SARS, 2021, Darazam, 2021, Darazam (COVIFERON Interferon beta-1a), 2021, Darazam (COVIFERON Interferon beta-1b), 2021, Davoudi-Monfared, 2020, DAWN-Plasma, 2021, Declercq J (COV-AID), 2021, DEVENT, 0, DEXA-COVID19, 2020, Edalatifard, 2020, EMPACTA, 2020, Esquivel-Moynelo, 2020, EU-CTR2020-001375-32 (PreToVid), 0, EU-CTR2020-001748-24 (ImmCoVA), 0, Fu, 2020, Gaitan-Duarte (Rosuvastatin plus colchicine), 2021, Gharebaghi, 2020, GLUCOCOVID, 2020, GRECCO-19, 2020, Hamed, 2021, Holm K, 2021, Horby, 2021, ILBS-COVID-02 (Bajpai M), 2020, ITAC, 2022, Jamaati, 2021, Kalil (ACTT-3), 2021, Kirenga, 2021, Kumar, 2021, LACCPT, 2021, Lanzoni, 2021, Lescure (Sarilumab 200mg), 2021, Lescure (Sarilumab 400mg), 2021, Li, 2020, Li, 2021, Libster, 2020, LIFESAVER, 2021, LIVE-AIR (Temesgen), 2021, Lopardo, 2021, Lopes MIF, 2020, Menichetti, 2021, Metcovid, 2020, Murugesan, 2022, NCT04377750 (HMO-0224-20), 0, NCT04385199, 2021, NCT04397757, 2021, NCT04403477 (two doses), 2021, NCT04412772 (ARCHITECTS), 0, NCT04434717 (COVITOZ-1 single dose plus two doses), 0, NCT04442191, 2021, NCT04479358 (COVIDOSE-2 substudy A 120mg plus 40mg), 0, NCT04528368, 2021, NCT04577534 (COVIDSTORM), 0, O’Donnell, 2021, Pandit, 2021, PC/COVID-19, 2021, PERUCONPLASMA, 2021, PICP19 (Ray), 2020, PLACID, 2020, PLACO-COVID, 2021, PlasmAr, 2020, Pouladzadeh, 2021, Rahmani, 2020, Raman, 2021, Ranjbar, 2021, Rashad, 2021, Rashad, 2021, Rasheed, 2020, RCT-TCZ-COVID-19, 2021, RECOVER, 2021, RECOVERY, 2021, RECOVERY, 2022, RECOVERY (colchicine), 2021, RECOVERY (plasma), 2021, RECOVERY (REGN-COV2), 2021, RECOVERY dexamethasone, 2020, REMAP-CAP (plasma), 2021, REMAP-CAP (tocilizumab), 2021, REMAP-CAP sarilumab, 2021, REMAP-CAP, fixed 7-day course, 2020, REMAP-CAP, shock-dependent course, 2020, Rosas (REMDACTA), 2021, Rutgers, 2021, Sakoulas, 2020, Salehzadeh, 2020, sarilumab phase 2 high dose, 0, sarimulab phase 2 low dose, 0, SAVE-MORE, 2021, Sekine (PLACOVID), 2021, Shashi Bhushan, 2021, Shi, 2020, Shu, 2020, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 2021, Soin AS (COVINTOC), 2021, SOLIDARITY (interferon), 2020, Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021, SPRINTER, 2022, Steroids-SARI, 2020, STOP-COVID (Guimarães), 2021, Synairgen SG016, 2020, Tabarsi, 2020, Talaschian, 2021, Tang X, 2020, TOCOVID, 0, Veiga, 2021, Wang, 202014234%91,727moderatecritical deaths (time to event analysis only)detailed resultsACTIV-3/ TICO (sotrovimab), 2021 1.02 [0.48; 2.17] ACTIV-3/TICO (tixa), 2022 0.70 [0.50; 0.97] ACTT-2 (Kalil), 2020 0.65 [0.39; 1.09] Balcells, 2020 3.26 [0.62; 17.12] Baldeon, 2022 1.85 [0.49; 6.97] Bennett-Guerrero, 2021 0.80 [0.26; 2.45] COLCOVID, 2021 0.88 [0.70; 1.11] CONCOR-1, 2021 1.02 [0.77; 1.36] ConPlas-19, 2020 0.46 [0.19; 1.15] COV-BARRIER, 2021 0.57 [0.41; 0.79] COVACTA (Rosas), 2020 1.16 [0.73; 1.84] CP-COVID-19, 2021 3.20 [0.62; 16.39] Davoudi-Monfared, 2020 0.38 [0.16; 0.87] DAWN-Plasma, 2021 0.99 [0.52; 1.88] Edalatifard, 2020 0.29 [0.15; 0.56] Kalil (ACTT-3), 2021 1.74 [0.51; 5.93] Lanzoni, 2021 0.11 [0.01; 0.93] LIVE-AIR (Temesgen), 2021 0.70 [0.40; 1.21] PlasmAr, 2020 0.93 [0.47; 1.85] Rashad, 2021 0.46 [0.24; 0.88] Rashad, 2021 2.16 [1.14; 4.09] REMAP-CAP, fixed 7-day course, 2020 0.94 [0.61; 1.45] REMAP-CAP, shock-dependent course, 2020 0.98 [0.63; 1.53] Rosas (REMDACTA), 2021 0.95 [0.65; 1.39] Rutgers, 2021 0.62 [0.36; 1.07] Talaschian, 2021 1.25 [0.30; 5.14] 0.82[0.69; 0.97]ACTIV-3/ TICO (sotrovimab), 2021, ACTIV-3/TICO (tixa), 2022, ACTT-2 (Kalil), 2020, Balcells, 2020, Baldeon, 2022, Bennett-Guerrero, 2021, COLCOVID, 2021, CONCOR-1, 2021, ConPlas-19, 2020, COV-BARRIER, 2021, COVACTA (Rosas), 2020, CP-COVID-19, 2021, Davoudi-Monfared, 2020, DAWN-Plasma, 2021, Edalatifard, 2020, Kalil (ACTT-3), 2021, Lanzoni, 2021, LIVE-AIR (Temesgen), 2021, PlasmAr, 2020, Rashad, 2021, Rashad, 2021, REMAP-CAP, fixed 7-day course, 2020, REMAP-CAP, shock-dependent course, 2020, Rosas (REMDACTA), 2021, Rutgers, 2021, Talaschian, 20212653%12,026moderatelow clinical deteriorationdetailed resultsBACC Bay Tocilizumab Trial, 2020 1.11 [0.59; 2.09] Balcells, 2020 1.46 [0.44; 4.81] Cao, 2020 0.11 [0.01; 2.21] CAPSID, 2021 0.63 [0.29; 1.40] CODEX (Tomazini), 2020 0.66 [0.43; 1.02] COL-COVID (Pascual-Figal), 2021 0.38 [0.09; 1.58] ConPlas-19, 2020 1.00 [0.65; 1.53] CONTAIN COVID-19, 2021 0.94 [0.75; 1.18] CORIMUNO-ANA-1, 2021 0.89 [0.42; 1.92] CORIMUNO-SARI-1 (non ICU), 2021 1.01 [0.48; 2.12] CORIMUNO-TOCI-1 (Group 1), 2020 0.56 [0.26; 1.20] COV-BARRIER, 2021 1.12 [0.58; 2.16] EMPACTA, 2020 0.55 [0.33; 0.92] Esquivel-Moynelo, 2020 2.29 [0.20; 26.58] GRECCO-19, 2020 0.11 [0.01; 1.08] Kirenga, 2021 0.91 [0.38; 2.17] Li, 2021 0.52 [0.02; 15.78] Libster, 2020 0.52 [0.29; 0.94] PLACID, 2020 1.04 [0.54; 1.99] Ravichandran, 2021 0.02 [0.00; 0.36] RCT-TCZ-COVID-19, 2021 1.05 [0.59; 1.86] SAVE-MORE, 2021 0.36 [0.26; 0.50] Shu, 2020 0.27 [0.01; 5.58] Soin AS (COVINTOC), 2021 0.67 [0.26; 1.77] SPRINTER, 2022 0.69 [0.43; 1.11] STOP-COVID (Guimarães), 2021 0.54 [0.27; 1.07] Synairgen SG016, 2020 0.50 [0.18; 1.38] Tang X, 2020 1.00 [0.13; 7.45] Wang, 2020 1.00 [0.02; 52.54] 0.72[0.60; 0.86]BACC Bay Tocilizumab Trial, 2020, Balcells, 2020, Cao, 2020, CAPSID, 2021, CODEX (Tomazini), 2020, COL-COVID (Pascual-Figal), 2021, ConPlas-19, 2020, CONTAIN COVID-19, 2021, CORIMUNO-ANA-1, 2021, CORIMUNO-SARI-1 (non ICU), 2021, CORIMUNO-TOCI-1 (Group 1), 2020, COV-BARRIER, 2021, EMPACTA, 2020, Esquivel-Moynelo, 2020, GRECCO-19, 2020, Kirenga, 2021, Li, 2021, Libster, 2020, PLACID, 2020, Ravichandran, 2021, RCT-TCZ-COVID-19, 2021, SAVE-MORE, 2021, Shu, 2020, Soin AS (COVINTOC), 2021, SPRINTER, 2022, STOP-COVID (Guimarães), 2021, Synairgen SG016, 2020, Tang X, 2020, Wang, 20202944%6,150moderatelow clinical improvementdetailed resultsACTIV-3/TICO (tixa), 2022 1.08 [0.97; 1.20] ACTIV-3/TICO LY-CoV555 , 2020 0.85 [0.56; 1.29] ACTT-2 (Kalil), 2020 1.16 [1.01; 1.33] BACC Bay Tocilizumab Trial, 2020 1.06 [0.80; 1.41] Balcells, 2020 0.91 [0.52; 1.60] Bennett-Guerrero, 2021 0.75 [0.21; 2.68] CAN-COVID, 2020 1.39 [0.76; 2.54] Cao, 2020 1.67 [0.84; 3.33] CAPSID, 2021 1.58 [0.71; 3.49] ConPlas-19, 2020 0.95 [0.60; 1.52] COV-BARRIER, 2021 1.25 [1.04; 1.50] COV-BARRIER (critically ill), 2022 2.87 [1.12; 7.36] COVACTA (Rosas), 2020 1.19 [0.81; 1.75] Darazam, 2021 1.37 [0.88; 2.13] Darazam (COVIFERON Interferon beta-1a), 2021 2.36 [1.09; 5.12] Davoudi-Monfared, 2020 1.10 [0.64; 1.88] Dongsheng Wang, 2020 2.37 [0.40; 13.96] Edalatifard, 2020 12.00 [2.39; 60.20] EMPACTA, 2020 1.15 [0.90; 1.47] ITAC, 2022 1.06 [0.77; 1.45] Kalil (ACTT-3), 2021 0.99 [0.87; 1.13] Lescure (Sarilumab 200mg), 2021 1.03 [0.75; 1.41] Li, 2020 1.40 [0.79; 2.49] Li, 2021 1.76 [1.10; 2.81] Lopardo, 2021 1.61 [0.75; 3.49] O’Donnell, 2021 1.20 [0.87; 1.65] PlasmAr, 2020 0.81 [0.50; 1.31] Pouladzadeh, 2021 7.31 [1.62; 32.97] REMAP-CAP (tocilizumab), 2021 1.64 [1.25; 2.15] REMAP-CAP sarilumab, 2021 1.76 [1.12; 2.78] REMAP-CAP, fixed 7-day course, 2020 1.43 [0.91; 2.26] REMAP-CAP, shock-dependent course, 2020 1.22 [0.76; 1.95] sarilumab phase 2 high dose, 0 2.09 [1.00; 4.36] sarimulab phase 2 low dose, 0 1.51 [0.73; 3.11] Sekine (PLACOVID), 2021 0.94 [0.74; 1.19] Shashi Bhushan, 2021 0.68 [0.21; 2.20] Shu, 2020 10.27 [1.17; 90.18] Singh (TD-0903 1mg), 2021 2.50 [0.16; 38.60] Singh (TD-0903 3mg), 2021 3.00 [0.20; 45.25] Synairgen SG016, 2020 2.32 [1.07; 5.04] Tang X, 2020 1.04 [0.67; 1.62] 1.21[1.12; 1.32]ACTIV-3/TICO (tixa), 2022, ACTIV-3/TICO LY-CoV555 , 2020, ACTT-2 (Kalil), 2020, BACC Bay Tocilizumab Trial, 2020, Balcells, 2020, Bennett-Guerrero, 2021, CAN-COVID, 2020, Cao, 2020, CAPSID, 2021, ConPlas-19, 2020, COV-BARRIER, 2021, COV-BARRIER (critically ill), 2022, COVACTA (Rosas), 2020, Darazam, 2021, Darazam (COVIFERON Interferon beta-1a), 2021, Davoudi-Monfared, 2020, Dongsheng Wang, 2020, Edalatifard, 2020, EMPACTA, 2020, ITAC, 2022, Kalil (ACTT-3), 2021, Lescure (Sarilumab 200mg), 2021, Li, 2020, Li, 2021, Lopardo, 2021, O’Donnell, 2021, PlasmAr, 2020, Pouladzadeh, 2021, REMAP-CAP (tocilizumab), 2021, REMAP-CAP sarilumab, 2021, REMAP-CAP, fixed 7-day course, 2020, REMAP-CAP, shock-dependent course, 2020, sarilumab phase 2 high dose, 0, sarimulab phase 2 low dose, 0, Sekine (PLACOVID), 2021, Shashi Bhushan, 2021, Shu, 2020, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 2021, Synairgen SG016, 2020, Tang X, 20204141%11,716moderatecritical clinical improvement (14-day)detailed resultsACTT-2 (Kalil), 2020 1.30 [1.03; 1.64] Cao, 2020 2.00 [0.58; 6.94] COV-BARRIER, 2021 1.28 [1.05; 1.56] COV-BARRIER (critically ill), 2022 1.97 [0.95; 4.09] Kalil (ACTT-3), 2021 1.01 [0.79; 1.29] Li, 2020 2.27 [0.90; 5.72] Li, 2021 2.86 [1.24; 6.62] Pandit, 2021 8.77 [0.94; 81.67] REMAP-CAP sarilumab, 2021 1.86 [1.20; 2.87] REMAP-CAP, fixed 7-day course, 2020 1.29 [0.82; 2.03] REMAP-CAP, shock-dependent course, 2020 1.03 [0.65; 1.64] Shashi Bhushan, 2021 0.68 [0.21; 2.20] Shu, 2020 10.27 [1.17; 90.18] Tang X, 2020 1.33 [0.57; 3.11] 1.37[1.15; 1.64]ACTT-2 (Kalil), 2020, Cao, 2020, COV-BARRIER, 2021, COV-BARRIER (critically ill), 2022, Kalil (ACTT-3), 2021, Li, 2020, Li, 2021, Pandit, 2021, REMAP-CAP sarilumab, 2021, REMAP-CAP, fixed 7-day course, 2020, REMAP-CAP, shock-dependent course, 2020, Shashi Bhushan, 2021, Shu, 2020, Tang X, 20201440%5,222moderatecritical clinical improvement (21-day)detailed resultsCao, 2020 1.50 [0.22; 10.08] 1.50[0.22; 10.08]Cao, 202010%41NAnot evaluable clinical improvement (28-day)detailed resultsBennett-Guerrero, 2021 1.02 [0.25; 4.20] COV-BARRIER (critically ill), 2022 1.82 [0.87; 3.81] COVACTA (Rosas), 2020 1.19 [0.81; 1.75] Li, 2020 1.42 [0.65; 3.10] Li, 2021 4.26 [1.10; 16.44] O’Donnell, 2021 1.38 [0.73; 2.61] Pouladzadeh, 2021 7.31 [1.62; 32.97] Sekine (PLACOVID), 2021 0.94 [0.74; 1.19] Shu, 2020 3.68 [0.18; 75.54] Singh (TD-0903 1mg), 2021 2.50 [0.16; 38.60] Singh (TD-0903 3mg), 2021 3.00 [0.20; 45.25] Synairgen SG016, 2020 3.15 [1.39; 7.14] 1.59[1.14; 2.21]Bennett-Guerrero, 2021, COV-BARRIER (critically ill), 2022, COVACTA (Rosas), 2020, Li, 2020, Li, 2021, O’Donnell, 2021, Pouladzadeh, 2021, Sekine (PLACOVID), 2021, Shu, 2020, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 2021, Synairgen SG016, 20201248%1,420moderatecritical clinical improvement (7-day)detailed resultsACTIV-3/TICO LY-CoV555 , 2020 0.85 [0.56; 1.29] Cao, 2020 2.38 [0.38; 14.70] ITAC, 2022 1.06 [0.77; 1.45] Li, 2020 0.98 [0.27; 3.58] Li, 2021 1.83 [0.41; 8.14] Shashi Bhushan, 2021 1.91 [1.03; 3.53] Shu, 2020 6.72 [1.50; 30.07] 1.32[0.90; 1.96]ACTIV-3/TICO LY-CoV555 , 2020, Cao, 2020, ITAC, 2022, Li, 2020, Li, 2021, Shashi Bhushan, 2021, Shu, 2020747%1,400moderatenot evaluable clinical improvement (time to event analysis only)detailed resultsACTT-2 (Kalil), 2020 1.16 [1.01; 1.33] Balcells, 2020 0.91 [0.52; 1.60] Bennett-Guerrero, 2021 0.75 [0.21; 2.68] Cao, 2020 1.67 [0.84; 3.33] ConPlas-19, 2020 0.95 [0.60; 1.52] Darazam, 2021 1.37 [0.88; 2.13] Darazam (COVIFERON Interferon beta-1a), 2021 2.36 [1.09; 5.12] Darazam (COVIFERON Interferon beta-1b), 2021 1.42 [0.63; 3.18] Davoudi-Monfared, 2020 1.10 [0.64; 1.88] EMPACTA, 2020 1.15 [0.90; 1.47] Kalil (ACTT-3), 2021 0.99 [0.87; 1.13] Lescure (Sarilumab 200mg), 2021 1.03 [0.75; 1.41] Lescure (Sarilumab 400mg), 2021 1.14 [0.84; 1.54] Li, 2020 1.40 [0.79; 2.49] Li, 2021 1.76 [1.10; 2.81] O’Donnell, 2021 1.20 [0.87; 1.65] PlasmAr, 2020 1.00 [0.76; 1.32] Rahmani, 2020 3.41 [1.33; 8.73] sarimulab phase 2 low dose, 0 0.96 [0.53; 1.73] SPRINTER, 2022 1.02 [0.81; 1.28] Tang X, 2020 1.04 [0.67; 1.62] 1.12[1.03; 1.21]ACTT-2 (Kalil), 2020, Balcells, 2020, Bennett-Guerrero, 2021, Cao, 2020, ConPlas-19, 2020, Darazam, 2021, Darazam (COVIFERON Interferon beta-1a), 2021, Darazam (COVIFERON Interferon beta-1b), 2021, Davoudi-Monfared, 2020, EMPACTA, 2020, Kalil (ACTT-3), 2021, Lescure (Sarilumab 200mg), 2021, Lescure (Sarilumab 400mg), 2021, Li, 2020, Li, 2021, O’Donnell, 2021, PlasmAr, 2020, Rahmani, 2020, sarimulab phase 2 low dose, 0, SPRINTER, 2022, Tang X, 20202111%4,870moderatecritical death or ventilationdetailed resultsACTT-2 (Kalil), 2020 0.69 [0.50; 0.95] BACC Bay Tocilizumab Trial, 2020 0.83 [0.38; 1.81] Balcells, 2020 0.67 [0.14; 3.26] CAPE-COVID, 2020 0.71 [0.37; 1.35] COLCOVID, 2021 0.83 [0.67; 1.02] CONCOR-1, 2021 1.16 [0.94; 1.43] ConPlas-19, 2020 0.94 [0.86; 1.02] CORIMUNO-ANA-1, 2021 0.97 [0.62; 1.52] CORIMUNO-SARI-1 (non ICU), 2021 1.12 [0.56; 2.22] CORIMUNO-TOCI-1 (Group 1), 2020 0.56 [0.24; 1.31] DAWN-Plasma, 2021 1.01 [0.64; 1.59] EMPACTA, 2020 0.56 [0.32; 0.97] LIVE-AIR (Temesgen), 2021 0.65 [0.43; 0.98] Menichetti, 2021 0.88 [0.59; 1.32] NCT04310228-FAVI (Zhao), 2020 3.60 [0.13; 102.66] RECOVERY, 2021 0.85 [0.78; 0.93] RECOVERY, 2022 0.90 [0.81; 0.99] RECOVERY (colchicine), 2021 1.02 [0.96; 1.09] RECOVERY (plasma), 2021 0.99 [0.93; 1.05] RECOVERY (REGN-COV2), 2021 0.83 [0.75; 0.92] RECOVERY dexamethasone, 2020 0.92 [0.84; 1.01] REMAP-CAP, fixed 7-day course, 2020 2.74 [1.16; 6.46] REMAP-CAP, shock-dependent course, 2020 1.24 [0.55; 2.78] Rosas (REMDACTA), 2021 0.98 [0.72; 1.34] Rutgers, 2021 0.65 [0.43; 0.99] sarilumab phase 2 high dose, 0 0.39 [0.18; 0.82] sarimulab phase 2 low dose, 0 0.70 [0.34; 1.44] SOLIDARITY (interferon), 2020 1.05 [0.90; 1.23] Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 0.66 [0.46; 0.94] SPRINTER, 2022 0.85 [0.45; 1.61] STOP-COVID (Guimarães), 2021 0.63 [0.41; 0.97] Synairgen SG016, 2020 0.38 [0.09; 1.63] Veiga, 2021 1.54 [0.65; 3.63] 0.90[0.85; 0.95]ACTT-2 (Kalil), 2020, BACC Bay Tocilizumab Trial, 2020, Balcells, 2020, CAPE-COVID, 2020, COLCOVID, 2021, CONCOR-1, 2021, ConPlas-19, 2020, CORIMUNO-ANA-1, 2021, CORIMUNO-SARI-1 (non ICU), 2021, CORIMUNO-TOCI-1 (Group 1), 2020, DAWN-Plasma, 2021, EMPACTA, 2020, LIVE-AIR (Temesgen), 2021, Menichetti, 2021, NCT04310228-FAVI (Zhao), 2020, RECOVERY, 2021, RECOVERY, 2022, RECOVERY (colchicine), 2021, RECOVERY (plasma), 2021, RECOVERY (REGN-COV2), 2021, RECOVERY dexamethasone, 2020, REMAP-CAP, fixed 7-day course, 2020, REMAP-CAP, shock-dependent course, 2020, Rosas (REMDACTA), 2021, Rutgers, 2021, sarilumab phase 2 high dose, 0, sarimulab phase 2 low dose, 0, SOLIDARITY (interferon), 2020, Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021, SPRINTER, 2022, STOP-COVID (Guimarães), 2021, Synairgen SG016, 2020, Veiga, 20213352%54,944moderatecritical hospital dischargedetailed resultsACTIV-3/TICO LY-CoV555 , 2020 0.97 [0.78; 1.20] CAPE-COVID, 2020 1.67 [0.87; 3.19] COLCHIVID, 2021 1.13 [0.76; 1.67] ConPlas-19, 2020 1.02 [0.82; 1.28] Davoudi-Monfared, 2020 1.96 [0.76; 5.03] DAWN-Plasma, 2021 1.06 [0.87; 1.30] EMPACTA, 2020 1.16 [0.90; 1.49] MARIPOSA, 2021 0.88 [0.55; 1.40] Rahmani, 2020 3.44 [0.64; 18.49] RECOVERY (colchicine), 2021 0.98 [0.94; 1.03] RECOVERY (plasma), 2021 0.99 [0.92; 1.07] RECOVERY (REGN-COV2), 2021 1.19 [1.08; 1.31] RECOVERY dexamethasone, 2020 1.10 [1.03; 1.17] Rosas (REMDACTA), 2021 0.97 [0.79; 1.20] Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021 1.48 [1.05; 2.09] SPRINTER, 2022 1.06 [0.89; 1.27] Synairgen SG016, 2020 1.63 [0.61; 4.35] 1.07[1.01; 1.13]ACTIV-3/TICO LY-CoV555 , 2020, CAPE-COVID, 2020, COLCHIVID, 2021, ConPlas-19, 2020, Davoudi-Monfared, 2020, DAWN-Plasma, 2021, EMPACTA, 2020, MARIPOSA, 2021, Rahmani, 2020, RECOVERY (colchicine), 2021, RECOVERY (plasma), 2021, RECOVERY (REGN-COV2), 2021, RECOVERY dexamethasone, 2020, Rosas (REMDACTA), 2021, Somersan-Karakaya (Cohort 1, Cohort 1A; Combined doses), 2021, SPRINTER, 2022, Synairgen SG016, 20201750%36,615moderatecritical hospitalizationdetailed resultsJagannathan, 2020 1.00 [0.14; 7.34] 1.00[0.14; 7.34]Jagannathan, 202010%120NAnot evaluable mechanical ventilationdetailed resultsACTT-2 (Kalil), 2020 0.64 [0.44; 0.93] AlQahtani, 2020 0.67 [0.22; 2.02] Balcells, 2020 2.98 [0.41; 21.61] CAPE-COVID, 2020 0.95 [0.44; 2.04] COL-COVID (Pascual-Figal), 2021 0.24 [0.01; 5.41] COPLA-II trial, 2020 0.58 [0.37; 0.92] COVACTA (Rosas), 2020 0.67 [0.39; 1.14] Darazam (COVIFERON Interferon beta-1a), 2021 1.00 [0.27; 3.67] Darazam (COVIFERON Interferon beta-1b), 2021 1.00 [0.27; 3.67] Davoudi-Monfared, 2020 0.72 [0.29; 1.76] Gaitan-Duarte (Rosuvastatin plus colchicine), 2021 0.85 [0.68; 1.06] GRECCO-19, 2020 0.17 [0.02; 1.48] Hamed, 2021 3.15 [0.57; 17.48] Holm K, 2021 0.39 [0.01; 12.68] Jamaati, 2021 1.38 [0.45; 4.20] Li, 2021 0.52 [0.02; 15.78] MARIPOSA, 2021 0.88 [0.37; 2.10] Metcovid, 2020 1.19 [0.56; 2.49] NCT04397757, 2021 0.41 [0.13; 1.35] O’Donnell, 2021 1.50 [0.47; 4.82] PLACID, 2020 0.99 [0.54; 1.81] PlasmAr, 2020 0.86 [0.39; 1.93] Rahmani, 2020 0.29 [0.05; 1.56] Ranjbar, 2021 0.36 [0.13; 0.97] RCT-TCZ-COVID-19, 2021 1.36 [0.39; 4.69] RECOVERY, 2022 0.87 [0.74; 1.02] RECOVERY (colchicine), 2021 1.04 [0.93; 1.16] RECOVERY (plasma), 2021 0.98 [0.88; 1.09] RECOVERY dexamethasone, 2020 0.77 [0.62; 0.95] Rutgers, 2021 0.65 [0.35; 1.24] Sakoulas, 2020 0.19 [0.03; 1.11] sarilumab phase 2 high dose, 0 0.27 [0.10; 0.71] sarimulab phase 2 low dose, 0 0.28 [0.11; 0.73] SAVE-MORE, 2021 0.47 [0.03; 7.48] Shu, 2020 0.59 [0.02; 14.04] Singh (TD-0903 1mg), 2021 0.09 [0.00; 2.48] Singh (TD-0903 3mg), 2021 0.08 [0.00; 2.07] Soin AS (COVINTOC), 2021 1.05 [0.46; 2.38] Tabarsi, 2020 1.49 [0.59; 3.78] 0.83[0.74; 0.92]ACTT-2 (Kalil), 2020, AlQahtani, 2020, Balcells, 2020, CAPE-COVID, 2020, COL-COVID (Pascual-Figal), 2021, COPLA-II trial, 2020, COVACTA (Rosas), 2020, Darazam (COVIFERON Interferon beta-1a), 2021, Darazam (COVIFERON Interferon beta-1b), 2021, Davoudi-Monfared, 2020, Gaitan-Duarte (Rosuvastatin plus colchicine), 2021, GRECCO-19, 2020, Hamed, 2021, Holm K, 2021, Jamaati, 2021, Li, 2021, MARIPOSA, 2021, Metcovid, 2020, NCT04397757, 2021, O’Donnell, 2021, PLACID, 2020, PlasmAr, 2020, Rahmani, 2020, Ranjbar, 2021, RCT-TCZ-COVID-19, 2021, RECOVERY, 2022, RECOVERY (colchicine), 2021, RECOVERY (plasma), 2021, RECOVERY dexamethasone, 2020, Rutgers, 2021, Sakoulas, 2020, sarilumab phase 2 high dose, 0, sarimulab phase 2 low dose, 0, SAVE-MORE, 2021, Shu, 2020, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 2021, Soin AS (COVINTOC), 2021, Tabarsi, 20203933%41,069moderatecritical mechanical ventilation (time to event analysis only)detailed resultsCP-COVID-19, 2021 0.66 [0.25; 1.72] DAWN-Plasma, 2021 1.08 [0.65; 1.80] 0.97[0.62; 1.52]CP-COVID-19, 2021, DAWN-Plasma, 202120%583moderatenot evaluable radiologic improvement (14-day)detailed resultsCao, 2020 5.54 [1.01; 30.50] Jamaati, 2021 4.89 [1.15; 20.79] NCT04310228-FAVI (Zhao), 2020 0.32 [0.06; 1.63] Rashad (CLARI vs SoC), 2021 2.87 [1.56; 5.28] Tabarsi, 2020 2.33 [0.45; 12.00] 2.38[1.04; 5.46]Cao, 2020, Jamaati, 2021, NCT04310228-FAVI (Zhao), 2020, Rashad (CLARI vs SoC), 2021, Tabarsi, 2020550%373moderatenot evaluable Recovery (time to event analysis only)detailed resultsSPRINTER, 2022 1.02 [0.81; 1.28] 1.02[0.81; 1.28]SPRINTER, 202210%623NAnot evaluable viral clearance detailed resultsBalcells, 2020 2.66 [0.69; 10.20] CP-COVID-19, 2021 1.12 [0.16; 7.84] Esquivel-Moynelo, 2020 3.26 [1.53; 6.95] Jagannathan, 2020 0.81 [0.56; 1.18] Li, 2021 7.68 [0.91; 65.15] Pandit, 2021 2.33 [0.55; 9.83] Raman, 2021 36.42 [10.85; 122.18] Ravichandran, 2021 1.71 [0.80; 3.64] Salman, 2020 1.00 [0.02; 53.89] Shashi Bhushan, 2021 2.77 [1.44; 5.32] Tang X, 2020 1.78 [1.06; 3.00] 2.60[1.42; 4.73]Balcells, 2020, CP-COVID-19, 2021, Esquivel-Moynelo, 2020, Jagannathan, 2020, Li, 2021, Pandit, 2021, Raman, 2021, Ravichandran, 2021, Salman, 2020, Shashi Bhushan, 2021, Tang X, 20201179%1,043moderatecritical viral clearance (time to event analysis only)detailed resultsEsquivel-Moynelo, 2020 3.26 [1.53; 6.95] Jagannathan, 2020 0.81 [0.56; 1.18] Li, 2021 1.74 [1.10; 2.75] Tang X, 2020 1.78 [1.06; 3.00] 1.60[0.92; 2.79]Esquivel-Moynelo, 2020, Jagannathan, 2020, Li, 2021, Tang X, 2020479%365moderatenot evaluable viral clearance by day 14detailed resultsCP-COVID-19, 2021 1.51 [0.33; 6.94] Esquivel-Moynelo, 2020 5.90 [0.28; 122.94] Kirenga, 2021 0.95 [0.76; 1.19] Li, 2021 1.74 [0.71; 4.29] Pandit, 2021 10.23 [1.12; 93.35] Raman, 2021 36.42 [10.85; 122.18] Shashi Bhushan, 2021 0.00 [0.00; 0.01] 1.38[0.20; 9.41]CP-COVID-19, 2021, Esquivel-Moynelo, 2020, Kirenga, 2021, Li, 2021, Pandit, 2021, Raman, 2021, Shashi Bhushan, 2021796%1,841moderatenot evaluable viral clearance by day 7detailed resultsBalcells, 2020 2.66 [0.69; 10.20] Esquivel-Moynelo, 2020 3.09 [1.04; 9.17] Kirenga, 2021 0.87 [0.65; 1.16] Li, 2021 2.20 [0.95; 5.10] Pandit, 2021 2.33 [0.55; 9.83] PLACID, 2020 1.20 [1.00; 1.44] Ravichandran, 2021 1.71 [0.80; 3.64] Salman, 2020 1.00 [0.02; 53.89] Shashi Bhushan, 2021 2.77 [1.44; 5.32] 1.57[1.13; 2.18]Balcells, 2020, Esquivel-Moynelo, 2020, Kirenga, 2021, Li, 2021, Pandit, 2021, PLACID, 2020, Ravichandran, 2021, Salman, 2020, Shashi Bhushan, 2021958%1,107moderateserious ICU admissiondetailed resultsCOL-COVID (Pascual-Figal), 2021 0.47 [0.08; 2.69] COVACTA (Rosas), 2020 0.48 [0.25; 0.94] CP-COVID-19, 2021 0.82 [0.35; 1.91] Darazam (COVIFERON Interferon beta-1a), 2021 1.00 [0.21; 4.71] Darazam (COVIFERON Interferon beta-1b), 2021 0.46 [0.11; 1.94] Gaitan-Duarte (Rosuvastatin plus colchicine), 2021 0.99 [0.56; 1.75] GLUCOCOVID, 2020 0.85 [0.27; 2.67] Hamed, 2021 3.15 [0.57; 17.48] Libster, 2020 0.33 [0.07; 1.58] Lopardo, 2021 0.67 [0.35; 1.28] Lopes MIF, 2020 1.06 [0.06; 18.45] Rahmani, 2020 0.37 [0.14; 1.00] Rutgers, 2021 0.96 [0.55; 1.68] Soin AS (COVINTOC), 2021 1.33 [0.67; 2.64] Tabarsi, 2020 0.56 [0.18; 1.74] Tang X, 2020 1.00 [0.13; 7.45] 0.79[0.63; 0.99]COL-COVID (Pascual-Figal), 2021, COVACTA (Rosas), 2020, CP-COVID-19, 2021, Darazam (COVIFERON Interferon beta-1a), 2021, Darazam (COVIFERON Interferon beta-1b), 2021, Gaitan-Duarte (Rosuvastatin plus colchicine), 2021, GLUCOCOVID, 2020, Hamed, 2021, Libster, 2020, Lopardo, 2021, Lopes MIF, 2020, Rahmani, 2020, Rutgers, 2021, Soin AS (COVINTOC), 2021, Tabarsi, 2020, Tang X, 2020160%2,019moderatelow off oxygenationdetailed resultsDavoudi-Monfared, 2020 8.57 [1.43; 51.36] ILBS-COVID-02 (Bajpai M), 2020 0.26 [0.02; 2.88] sarilumab phase 2 high dose, 0 1.99 [0.95; 4.15] sarimulab phase 2 low dose, 0 1.07 [0.52; 2.21] 1.62[0.67; 3.92]Davoudi-Monfared, 2020, ILBS-COVID-02 (Bajpai M), 2020, sarilumab phase 2 high dose, 0, sarimulab phase 2 low dose, 0458%331seriousnot evaluable recoverydetailed resultsACTIV-3 (BRII-196 and BRII-198), 2021 1.08 [0.88; 1.32] ACTIV-3/ TICO (sotrovimab), 2021 1.12 [0.91; 1.37] ACTIV-3/TICO LY-CoV555 , 2020 1.06 [0.77; 1.46] COV-BARRIER (critically ill), 2022 1.57 [0.77; 3.20] Lanzoni, 2021 3.46 [1.05; 11.35] Synairgen SG016, 2020 2.19 [1.03; 4.67] Talaschian, 2021 0.64 [0.14; 2.92] 1.17[0.98; 1.39]ACTIV-3 (BRII-196 and BRII-198), 2021, ACTIV-3/ TICO (sotrovimab), 2021, ACTIV-3/TICO LY-CoV555 , 2020, COV-BARRIER (critically ill), 2022, Lanzoni, 2021, Synairgen SG016, 2020, Talaschian, 2021725%1,290lownot evaluable composite safety outcome detailed resultsACTIV-3/TICO LY-CoV555 , 2020 1.56 [0.78; 3.11] 1.56[0.78; 3.11]ACTIV-3/TICO LY-CoV555 , 202010%314NAnot evaluable related AE (TRAE)detailed resultsSingh (TD-0903 1mg), 2021 2.50 [0.16; 38.60] Singh (TD-0903 3mg), 2021 0.38 [0.01; 13.93] 1.26[0.14; 11.07]Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 202120%25moderatenot evaluable related SAE (TRSAE)detailed resultsWang, 2020 2.04 [0.07; 63.93] 2.04[0.07; 63.93]Wang, 202010%48NAnot evaluable serious adverse eventsdetailed resultsBACC Bay Tocilizumab Trial, 2020 1.21 [0.58; 2.53] Balcells, 2020 4.54 [0.20; 105.23] CAN-COVID, 2020 0.73 [0.45; 1.19] Cao, 2020 0.11 [0.01; 2.21] CODEX (Tomazini), 2020 0.53 [0.17; 1.62] COL-COVID (Pascual-Figal), 2021 0.24 [0.01; 5.41] CONCOR-1, 2021 1.27 [1.02; 1.58] ConPlas-19, 2020 0.89 [0.43; 1.86] COVACTA (Rosas), 2020 0.81 [0.54; 1.22] Dongsheng Wang, 2020 0.91 [0.02; 47.31] Edalatifard, 2020 0.81 [0.11; 6.17] ITAC, 2022 0.98 [0.66; 1.46] Jagannathan, 2020 1.00 [0.14; 7.34] Lanzoni, 2021 0.10 [0.01; 0.69] Lescure (Sarilumab 200mg), 2021 1.15 [0.62; 2.12] Lescure (Sarilumab 400mg), 2021 1.38 [0.76; 2.51] O’Donnell, 2021 0.64 [0.35; 1.17] Pandit, 2021 0.95 [0.02; 50.33] PlasmAr, 2020 1.40 [0.78; 2.51] Raman, 2021 0.49 [0.02; 15.10] REMAP-CAP (plasma), 2021 2.28 [1.17; 4.46] REMAP-CAP, fixed 7-day course, 2020 3.01 [0.33; 27.32] REMAP-CAP, shock-dependent course, 2020 3.68 [0.42; 31.96] Rosas (REMDACTA), 2021 0.83 [0.59; 1.18] Sekine (PLACOVID), 2021 1.14 [0.88; 1.48] Shi, 2020 1.08 [0.04; 32.96] Soin AS (COVINTOC), 2021 0.97 [0.44; 2.13] Talaschian, 2021 7.93 [0.37; 171.38] Veiga, 2021 1.66 [0.60; 4.59] 1.04[0.90; 1.20]BACC Bay Tocilizumab Trial, 2020, Balcells, 2020, CAN-COVID, 2020, Cao, 2020, CODEX (Tomazini), 2020, COL-COVID (Pascual-Figal), 2021, CONCOR-1, 2021, ConPlas-19, 2020, COVACTA (Rosas), 2020, Dongsheng Wang, 2020, Edalatifard, 2020, ITAC, 2022, Jagannathan, 2020, Lanzoni, 2021, Lescure (Sarilumab 200mg), 2021, Lescure (Sarilumab 400mg), 2021, O’Donnell, 2021, Pandit, 2021, PlasmAr, 2020, Raman, 2021, REMAP-CAP (plasma), 2021, REMAP-CAP, fixed 7-day course, 2020, REMAP-CAP, shock-dependent course, 2020, Rosas (REMDACTA), 2021, Sekine (PLACOVID), 2021, Shi, 2020, Soin AS (COVINTOC), 2021, Talaschian, 2021, Veiga, 20212919%8,651moderatelow superinfectiondetailed resultsACTT-2 (Kalil), 2020 0.50 [0.32; 0.79] CAPE-COVID, 2020 0.81 [0.49; 1.34] Davoudi-Monfared, 2020 2.41 [0.75; 7.73] Metcovid, 2020 0.98 [0.65; 1.47] Rahmani, 2020 0.18 [0.02; 1.59] 0.80[0.50; 1.27]ACTT-2 (Kalil), 2020, CAPE-COVID, 2020, Davoudi-Monfared, 2020, Metcovid, 2020, Rahmani, 2020561%1,722moderatenot evaluable adverse eventsdetailed resultsCao, 2020 1.60 [0.38; 6.81] COL-COVID (Pascual-Figal), 2021 1.72 [0.73; 4.08] COLCHIVID, 2021 1.63 [0.67; 3.95] COVACTA (Rosas), 2020 0.87 [0.52; 1.45] Dongsheng Wang, 2020 9.64 [2.76; 33.75] Esquivel-Moynelo, 2020 1.33 [0.45; 3.92] Jagannathan, 2020 1.33 [0.63; 2.78] Kirenga, 2021 1.13 [0.50; 2.58] Lanzoni, 2021 0.18 [0.02; 1.95] Lescure (Sarilumab 200mg), 2021 0.97 [0.56; 1.69] Lescure (Sarilumab 400mg), 2021 1.31 [0.76; 2.27] NCT04310228-FAVI (Zhao), 2020 0.60 [0.05; 6.80] Pandit, 2021 1.68 [0.47; 5.97] Raman, 2021 1.36 [0.56; 3.30] Ravichandran, 2021 1.04 [0.02; 52.86] Rosas (REMDACTA), 2021 1.32 [0.92; 1.89] Sakoulas, 2020 1.00 [0.02; 53.46] Sekine (PLACOVID), 2021 1.08 [0.85; 1.38] Shi, 2020 0.88 [0.38; 2.03] Shu, 2020 2.48 [0.05; 132.54] Singh (TD-0903 1mg), 2021 0.45 [0.01; 16.71] Singh (TD-0903 3mg), 2021 0.04 [0.00; 1.01] Soin AS (COVINTOC), 2021 1.50 [0.78; 2.87] Veiga, 2021 1.65 [0.81; 3.37] Wang, 2020 3.57 [0.93; 13.72] 1.25[1.06; 1.48]Cao, 2020, COL-COVID (Pascual-Figal), 2021, COLCHIVID, 2021, COVACTA (Rosas), 2020, Dongsheng Wang, 2020, Esquivel-Moynelo, 2020, Jagannathan, 2020, Kirenga, 2021, Lanzoni, 2021, Lescure (Sarilumab 200mg), 2021, Lescure (Sarilumab 400mg), 2021, NCT04310228-FAVI (Zhao), 2020, Pandit, 2021, Raman, 2021, Ravichandran, 2021, Rosas (REMDACTA), 2021, Sakoulas, 2020, Sekine (PLACOVID), 2021, Shi, 2020, Shu, 2020, Singh (TD-0903 1mg), 2021, Singh (TD-0903 3mg), 2021, Soin AS (COVINTOC), 2021, Veiga, 2021, Wang, 20202512%3,212moderatelow0.55.01.0relative treatment effectwww.metaEvidence.org2024-05-24 02:51 +02:00

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;

pathologies: 95,94,90,91 - treatments: 546,564,944,682,1266,943,894,560,1102,598,563,668,753,752,836,639,541,534,581,615,679,522,582,666,1149,1150,737,544,733,597,524,611,538,957,958,521,566,517,881,904,882,897,896,899,1235,898,687,740,883,947,536,591,729,887,742,878,975,570,771,888,1141,690,880,1255,567,596,1437,600,652,557,635,1236,553,628,646,645,607,395,920,1438,927,932,931,1263,599,614,942,1436,928,923,535,1046,727,818,606,954,964,962,963,1045,638,677,627,533,526,616,926,1246,726,580,568,527,588,539,585,691,1210,525 - roots T: 290