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Zhang, 2020 NCT04264533

vitamin C (n=27) vs. placebo (n=29)

randomized controlled trial

High-dose intravenous Vitamin C
24 g vitamin C per day. Patients were infused with 12 g vitamin C diluted in 50 ml of bacteriostatic water every 12 h at a rate of 12 ml/hour by infusion pump for 7 days.

Placebo
50 ml of bacteriostatic water infused every 12 h at a rate of 12 ml/hour by infusion pump for 7 days.

Patients were randomized to receive vitamin C or placebowithin 48 h after admission to the ICU.

COVID-19 severe or critically

(1) age ≥ 18 and < 80 years; (2) RTPCR positive for SARS-CoV-2; (3) pneumonia confirmed by chest imaging and admission to the ICU; (3) PaO2/ FiO2(P/F) < 300 mmHg.

Double-blind.

Multicenter, 3 hospitals in Hubei, China.