chloroquine and derivatives for COVID-19 - living meta-analysis of clinical studies

meta|evidence COVID-19

Living systematic review and meta-analysis

vs. potential COVID-19 treatments
vs. antiviral and associated therapy
vs. azithromycin
vs. lopinavir/ritonavir
vs. control
vs. placebo
vs. standard of care
vs. Vitamins
vs. vitamin C

All
COVID 19 hospitalized
COVID 19 all comers
COVID-19 mild to moderate
COVID-19 severe or critically
COVID 19 outpatients
COVID-19 (hospitalized or not)
COVID-19 prophylaxis (children)
COVID-19 prophylaxis (excluding children)
infections other than COVID-19
Long COVID-19
preventing respiratory virus transmission
root
secondary prevention

Studies
Mapping
Meta-analysis
Excluded 4

table network network 2

display ongoing demontrated benefit only

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Thakar, 2021

chloroquine vs. standard of care

COVID 19 outpatients

HyAzOUT, 0 NCT04334382

chloroquine and derivatives vs. azithromycin

COVID 19 outpatients

NCT04342169, 0 NCT04342169

chloroquine and derivatives vs. placebo

COVID 19 outpatients

ALBERTA HOPE-Covid19, 2021 NCT04329611

chloroquine and derivatives vs. placebo

COVID 19 outpatients

QUARANTINE2020, 0 NCT04331600

chloroquine and derivatives vs. standard of care

COVID 19 outpatients

NCT04333628, 0 NCT04333628

chloroquine and derivatives vs. standard of care

COVID 19 outpatients

NCT04334967, 0 NCT04334967

chloroquine and derivatives vs. standard of care

COVID 19 outpatients

Agusti, 2020

hydroxychloroquine vs. control

COVID 19 outpatients

COPE – Coalition V, 2022 NCT04466540

hydroxychloroquine vs. placebo

COVID 19 outpatients

COMIHY, 2020 NCT04340544

hydroxychloroquine vs. placebo

COVID 19 outpatients

Q-PROTECT -HCQ alone, 2020 NCT04349592

hydroxychloroquine vs. placebo

COVID 19 outpatients

COVID-PEP Severity (Skipper), 2020 NCT04308668

hydroxychloroquine vs. placebo

COVID 19 outpatients

Reis (Hydroxychloroquine) (TOGETHER), 2021 NCT04403100

hydroxychloroquine vs. placebo

COVID 19 outpatients

Kanran M, 2020 NCT04491994

hydroxychloroquine vs. standard of care

COVID 19 outpatients

NCT04597775, 0 NCT04597775

hydroxychloroquine vs. standard of care

COVID 19 outpatients

PATCH Cohort 1 (Amaravadi), 2021 NCT04329923

hydroxychloroquine vs. standard of care

COVID 19 outpatients

BCN PEP-CoV-2-Study 2 (Mitja et al. Clin Infect Dis), 2020 NCT04304053

hydroxychloroquine vs. standard of care

COVID 19 outpatients

BCN PEP-CoV-2-Study 2 (Mitja Lancet-preprint), 2020 NCT04304053

hydroxychloroquine vs. standard of care

COVID 19 outpatients

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