meta
|
evidence
COVID-19
Living systematic review and meta-analysis
potential COVID-19 treatments
All
potential COVID-19 treatments
adjuvant therapies
anticoagulant
anticoagulant, curative dose
anticoagulant, pre-admission
anticoagulant, prophylactic dose
anticoagulation, intermediate prophylactic dose
Bivalirudin
enoxaparin
heparin at therapeutic dose
P2Y12 inhibitors
rivaroxaban
sulodexide
face mask
febuxostat
hydrogen-oxygen nebulizer
hyperbaric oxygen
nintedanib
paracetamol
pulmonary rehabilitation
anti-inflammatoty and immuno-therapy
anti-inflammatory therapies
anti GM-CSF
mavrilimumab
otilimab
clarithromycine
colchicine
Colchicine plus rosuvastatin
mepolizumab
naproxen, ibuprofen
non-steroidal anti-inflammatory drugs
Celecoxib
Ibuprofen
Indomethacin
selinexor
sodium aescinate
stem cells
tradipitant
vilobelimab (IFX-1)
Apilimod
corticosteroids
ciclesonide
dexamethasone
Dexamethasone 12mg
dexamethasone 6mg
Hydrocortisone
low-dose corticosteroids
methylprednisolone
Immunostimulants drugs
anti-PD-1 antibody
CD24Fc
convalescent plasma treatment
Deferred Convalescent plasma
Early convalescent plasma.
immunoglobulin therapy
inactivated mycobacterium vaccine
interferon
IFN beta-1a
high-dose IFN beta-1a
IFN beta-1b
IFN gamma
inhaled interferon
IFN alpha
pegylated interferon-α2b
recombinant super-compound interferon rSIFN-co
SNG001 inhaled interferon beta
interferon / TFF2
peginterferon
PNB001
Interleukin-2
levamisole
neutralizing antibody
amubarvimab/romlusevimab (BRII-196 and BRII-198-Brii Biosciences)
bamlanivimab monotherapy
bamlanivimab/etesevimab
Bebtelovimab (LY-CoV1404)
bevacizumab
cilgavimab and tixagevimab (Evusheld)
equine polyclonal antibodies INM005
regdanvimab (Regkirona- CT-P59-Celltrion)
sotrovimab (Xevudy; VIR-7831)
XAV-19
rhG-CSF
Immunosuppressants drugs
adalimumab
anakinra
anti-interleukin-6
clazakizumab
Levilimab
sarilumab
sarilumab azithromycin hydroxychloroquine
sarilumab high dose (400mg)
sarilumab low dose (200mg)
siltuximab
tocilizumab
canakinumab
complement inhibitors
conestat alfa
ravulizumab
CRAC-channel inhibitors (auxora)
eculizumab
emapalumab
fostamatinib
itolizumab
ixekizumab
jakotinib
janus kinase (JAK) inhibitor
baricitinib
baricitinib plus remdesivir
ruxolitinib
TD-0903
TD-0903 10mg
TD-0903 1mg
TD-0903 3mg
tofacitinib
lenzilumab
pamrevlumab
tacrolimus
tetrandrine
thalidomide
inhaled corticosteroids
budesonide
Kinase inhibitors
acalabrutinib
imatinib
leflunomide
meplazumab
pirfenidone
Polyinosinic-Polycytidylic Acid
sargramostim
statins
Atorvastatin
thymosin
antiandrogenic
5-alpha-reductase inhibitors
dutasteride
progesterone
proxalutamide
antiviral and associated therapy
ASC09/ritonavir
azithromycin
azvudine
baloxavir marboxil
bromhexine
carrimycin
chloroquine and derivatives
chloroquine
hydroxychloroquine
zinc plus hydroxychloroquine
danoprevir / ritonavir
darunavir cobicistat
darunavir/cobicistat plus chloroquine
doxycycline
Emtricitabine/tenofovir plus colchicine plus rosuvastatin
favipiravir
favipiravir plus interferon
fluvoxamine
hydroxychloroquine plus macrolides
azithromycin plus hydroxychloroquine
Interferon plus lopinavir/ritonavir
ivermectin
ivermectin plus doxycycline
leronlimab
lopinavir / ritonavir plus ribavirin
lopinavir/ritonavir
lopinavir/ritonavir plus chloroquine
Lopinavir/ritonavir plus hydroxychloroquine
lopinavir/ritonavir plus interferon ß-1a
lopinavir/ritonavir, ribavirin and interferon beta-1b
molnupiravir
niclosamide
nirmatrelvir / ritonavir (Paxlovid)
nitazoxanide
opaganib
oseltamivir
oseltamivir plus chloroquin
remdesivir
ribavirin
ritonavir
sofosbuvir
sofosbuvir and daclatasvir
sofosbuvir and ledipasvir
tenofovir/emtricitabine
tenofovir/emtricitabine plus hydroxychloroquine
tranexamic acid
tranilast
triazavirin
umifenovir (arbidol)
zinc
control
placebo
prone positioning
standard of care
miscellaneous
acetylcysteine
alpha lipoic acid
anti-CK2
Aspirin
aviptadil
calcium channel blocker
camostat mesilate
Cannabidiol
continuous positive airway pressure (CPAP)
cytokine adsorption
diammonium glycyrrhizinate
dipyridamol
dornase alfa
expectorants and mucolytics
kinin-kallikrein inhibitors
melatonin
mouthrise and gargling agents
mouthrinses
N-Acetylcysteine
nasal spray
nasal spray containing Iota-Carrageenan
natural killer (NK) cells
nicotin
nigella sativa oil
nitric oxide (gas Inhalation or releasing solution)
omega-3 Polyunsaturated Fatty Acids
ozonated autohemotherapy
plasma exchange
povidone-iodine
previfenon (EGCG)
prostacyclin
PUL-042 inhalation solution
pyridostigmine
radiotherapy
sabizabulin
sildenafil
triiodothyronine (T3)
Oral antidiabetic drugs
dapagliflozin
DPP-4 inhibitor
metformin
Renin-angiotensin-system-acting agents
angiotensin converting enzyme inhibitors (ACEIs)
angiotensin receptor blockers (ARBs)
losartan
angiotensin-(1-7)
continuation of ACEI/ARB
discontinuation of ACEI/ARB
RAS blocker withdrawal
rhACE2
vaccines
BCG vaccination
CoVLP (MT-2766, Medicago)
DNA vaccine
Zy-Cov-D (Zydus Cadila)
ebola vaccine
first booster dose
heterologous prime-boost
Inactivated virus vaccine
CoronaVac (SinoVac)
Covaxin, Bharat Biotech (BBV152)
Shifa-Pharmed inactivated vaccine
Sinopharm Beijing (BBIBP-CorV)
Sinopharm Wuhan
mRNA vaccine
Comirnaty (tozinameran - Pfizer/BIONTECH)
CureVac
Spikevax (Moderna mRNA-1273 COVID-19 vaccine)
Non replicating viral vector
Ad26.RSV.preF (respiratory syncytial virus)
Ad26.ZEBOV ()
Ad26.ZIKV.001 (Ad26-Vectored Anti-Zika Virus Vaccine)
CanSino (Convidecia)
Covishield (Oxford/AZ formulation)
Janssen AD26 vaccine (JNJ-78436735)
Sputnik V (Gam-COVID-Vac)
Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19)
protein subunit vaccine
Anhui Zhifei Longcom
CoVax-19 SpikoGen
Nuvaxovid (NVX-CoV2373) Novavax
Sanofi/GSK recombinant protein vaccine
SCB-2019
Replicating Viral Vector
seasonal influenza vaccines
virus-like particles vaccine
Medicago
Vitamins
vitamin C
zinc plus vitamin c
Vitamin D
All
COVID 19 hospitalized
COVID 19 all comers
COVID-19 mild to moderate
COVID-19 severe or critically
COVID 19 outpatients
COVID-19 (hospitalized or not)
COVID-19 prophylaxis (children)
COVID-19 prophylaxis (excluding children)
infections other than COVID-19
Long COVID-19
preventing respiratory virus transmission
root
secondary prevention
vs. potential COVID-19 treatments
vs. control
vs. uncontrolled study
patient subgroup...
age >= 65 yr
alpha variant (B.1.1.7, UK)
delta variant (B.1.617.2, Indian)
fully vaccinated
healthcare workers
kidney transplant recipients
omicron variant BA.1 (B.1.1.529)
solid organ transplant recipients
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
Studies
Mapping
Meta-analysis
Excluded
1
table
network
network 2
select an endpoint to display result....
display studies
----
death D28
death or transfer to ICU
deaths
deaths (time to event analysis only)
clinical deterioration
clinical improvement
clinical improvement (14-day)
clinical improvement (21-day)
clinical improvement (28-day)
clinical improvement (7-day)
clinical improvement (time to event analysis only)
death or ventilation
hospital discharge
hospitalization
mechanical ventilation
mechanical ventilation (time to event analysis only)
radiologic improvement (14-day)
radiologic improvement (7-day)
Recovery (time to event analysis only)
viral clearance
viral clearance (time to event analysis only)
viral clearance by day 14
viral clearance by day 7
ICU admission
Major thrombotic events or death
off oxygenation
recovery
severe COVID-19 occurrence
color = results
color = ROB
demonstrated
suggested
inconclusive
safety concern
ongoing study
not assessable
low
moderate
serious
ongoing study
display ongoing
demontrated benefit only
observational study
COVID 19 all comers
COVID-19 mild to moderate
COVID-19 severe or critically
COVID 19 hospitalized
COVID 19 all comers
COVID-19 mild to moderate
COVID-19 severe or critically
potential COVID-19 treatments
adjuvant therapies
anticoagulant
Paranjpe
X-COVID-19
anticoagulant, curative dose
Bousquet
Bousquet
COALIZAO ACTION
ATTACC, ACTIV-4a, and REMAP-CAP ...
REMAP-CAP, ACTIV-4a, ATTACC ...
COVID-PACT
anticoagulant, prophylactic dose
Bousquet
Bousquet
Tang
anticoagulation, intermediate prophylactic dose
INSPIRATION
heparin at therapeutic dose
RAPID ...
ATTACC ...
ACTIV-4a ...
REMAP-CAP Anticoagulation
anti-inflammatoty and immuno-therapy
anti-inflammatory therapies
Malgorzata
anti GM-CSF
mavrilimumab
MASH-COVID ...
clarithromycine
Tsiakos
Rashad ...
colchicine
COLCOVID
Scarsi
Lopes MIF
Salehzadeh
GRECCO-19
RECOVERY ...
Horby
Sandhu
COL-COVID ...
COLCHIVID
Brunetti
Colchicine plus rosuvastatin
COLSTAT
Gaitan-Duarte ...
non-steroidal anti-inflammatory drugs
Jeong
Bruce
Imam
Drake
Guzman-Esquivel
Celecoxib
Wenxin
Indomethacin
Ravichandran
Ravichandran
stem cells
Lanzoni
Carmenate ...
Shu
Shi
vilobelimab (IFX-1)
PANAMO
corticosteroids
Fernández Cruz
GLUCOCOVID
Rahman
Albani
SAM-COVID-19
Rodriguez-Bano ...
Rodriguez-Bano ...
Li ...
Majmundar
Lu
Raef
Jianfeng
Tomasz
Salton ...
Monreal
dexamethasone
RECOVERY dexamethasone
DEXA-COVID19
CODEX ...
Jamaati
Rashad
Naik
Dexamethasone 12mg
COVID STEROID 2
Hydrocortisone
CAPE-COVID
REMAP-CAP, fixed 7-day course
REMAP-CAP, shock-dependent course
Munch ...
methylprednisolone
Tang X
Metcovid
Ranjbar
Steroids-SARI
Edalatifard
Farahani
Belhassen-Garc??a
Immunostimulants drugs
convalescent plasma treatment
ConCOVID ...
Abolghasemi
Salazar
ConPlas-19
COP-COVID-19
CONTAIN COVID-19
PC/COVID-19
NCT04397757
PLACO-COVID
CONCOR-1
CPC-SARS
NCT04442191
DAWN-Plasma
NCT04385199
COPLA-II trial
NCT04403477 ...
ASCOT
RECOVERY ...
CONFIDENT
PERUCONPLASMA
Bennett-Guerrero
Salman
Kirenga
LACCPT
Co-CLARITY
NCT04528368
Holm K
CCAP-2
Baldeon
Menichetti
LIFESAVER
PLACID
Libster
CP-COVID-19
ILBS-COVID-02 ...
Duan
Li
Sean
Rasheed
Hegerova
O’Donnell
PlasmAr
CAPSID
AlQahtani
Joyner
REMAP-CAP ...
RECOVER
PICP19 ...
Bihariesingh-Sanchit ...
Pouladzadeh
Sekine ...
Ray
Early convalescent plasma.
Balcells
immunoglobulin therapy
Sakoulas
Parikh
Tabarsi
Gharebaghi
Raman
interferon
Wang ...
Wang
Cai -FAVIPIRAVIR
Cai -FAVIPIRAVIR
IFN beta-1a
SOLIDARITY ...
Davoudi-Monfared
Darazam ...
Kalil ...
high-dose IFN beta-1a
Darazam
IFN beta-1b
Rahmani
Darazam ...
IFN gamma
Esquivel-Moynelo
inhaled interferon
IFN alpha
pegylated interferon-α2b
Pandit
Shashi Bhushan
recombinant super-compound interferon rSIFN-co
Li
SNG001 inhaled interferon beta
Synairgen SG016
SPRINTER
interferon / TFF2
Fu
peginterferon
Jagannathan
PNB001
Lattmann
neutralizing antibody
ITAC
amubarvimab/romlusevimab (BRII-196 and BRII-198-Brii Biosciences)
ACTIV-3 ...
bamlanivimab monotherapy
ACTIV-3/TICO LY-CoV555
casirivimab/imdevimab (Ronapreve)
RECOVERY ...
Somersan-Karakaya ...
Suzuki
cilgavimab and tixagevimab (Evusheld)
ACTIV-3/TICO ...
Chen
equine polyclonal antibodies INM005
Lopardo
sotrovimab (Xevudy; VIR-7831)
ACTIV-3/ TICO ...
Immunosuppressants drugs
abatacept
ACTIV-1 abatacept
adalimumab
Fakharian
anakinra
SAVE-MORE
CORIMUNO-ANA-1
Ana-COVID ...
Kooistra
anti-interleukin-6
Levilimab
V.Lomakin ...
sarilumab
CORIMUNO-SARI-1 ...
sarilumab Sanofi phase 3 US
ARI-RAF ...
sarilumab Sanofi phase 3 outside US
REMAP-CAP sarilumab
sarilumab high dose (400mg)
sarilumab phase 2 high dose
Lescure ...
sarilumab low dose (200mg)
sarimulab phase 2 low dose
Lescure ...
tocilizumab
Dongsheng Wang
RCT-TCZ-COVID-19
Martinez-Sanz
HNF Hospital Tocilizumab multidisciplinary team
Colaneri
EMPACTA
Tsai
SAM-COVID-19
RECOVERY
Soin AS ...
Rutgers
NCT04412772 ...
Declercq J ...
NCT04577534 ...
EU-CTR2020-001375-32 ...
EU-CTR2020-001748-24 ...
NCT04479358 ...
NCT04434717 ...
TOCOVID
BACC Bay Tocilizumab Trial
Capra
TOCI-RAF Study Group ...
Rojas-Marte
Somers
Mathilde
Andrew
MARIPOSA
Biran
COVACTA ...
Pereira
CORIMUNO-TOCI-1 ...
REMAP-CAP ...
Veiga
Rashad
Talaschian
Hamed
Karampitsakos
CORIMUNO-TOCI-ICU ...
NCT04377750 ...
Rosas ...
Karakike ...
Belhassen-Garc??a
Sarhan
Sarhan
canakinumab
Sheng ...
CAN-COVID
cenicriviroc
ACTIV-1 cenicriviroc
infliximab
ACTIV-1 infliximab
itolizumab
Kumar
janus kinase (JAK) inhibitor
baricitinib
COV-BARRIER
ACTT-2 ...
RECOVERY
Rodriguez-Garcia
Cantini
Tziolos
COV-BARRIER ...
ruxolitinib
Cao
DEVENT
TD-0903
TD-0903 10mg
Singh ...
TD-0903 1mg
Singh ...
TD-0903 3mg
Singh ...
tofacitinib
STOP-COVID ...
Murugesan
lenzilumab
LIVE-AIR ...
tacrolimus
TACROVID
thalidomide
Amra
Kinase inhibitors
acalabrutinib
CALAVI
CALAVI US
imatinib
Covid-19 HUF
Aman
leflunomide
Wang et al.
Wang
statins
Atorvastatin
INSPIRATION-S
antiandrogenic
progesterone
Ghandehari
proxalutamide
Cadegiani
antiviral and associated therapy
azithromycin
Rosenberg
Sekhavati
Rodriguez-Molinero
RECOVERY ...
COALITION I Covid-19 Brazil ...
Espitia-Hernandez
Rashad A ...
COALITION II Covid-19 Brazil ...
azvudine
Ren
baloxavir marboxil
Lou Y
bromhexine
Ansarin
Tolouian
Li T
chloroquine and derivatives
Rosenberg
Karolyi
chloroquine
Chen_chloroquine
Huang
Huang
Chen, ChiCTR2000030054 - Chloroquine
NCT04342650
hydroxychloroquine
Tang
HAHPS
ORCHID
Duke University hydroxychloroquine/azithromycine
Magagnoli ...
Geleris
Novales
RECOVERY
Paccoud
Sbidian ...
SOLIDARITY ...
Arshad ...
Chen
NO COVID-19 ...
Kalligeros
Belgian Collaborative Group on COVID-19
Abd-Elsalam
Cravedi
Fontana
Singh
CCAP-1
Duke university HCQ
ARCHAIC -hydroxychloroquine
PROTECT B
TEACH
OAHU-COVID19
HYCOVID
IRCT20200428047228N1 // U07
Gonzalez ...
PROTECT A
Gautret et al.
ChiCTR2000030054-HCQ ...
IRCT20150808023559N20
IRCT20150808023559N20
NCT04376814-Group A
NCT04376814-Group A
NOR-Solidarity ...
HC-nCoV ...
Zhaowei Chen
Coalition Covid-19 Brazil I ...
Min
NCT04333654
FACCT Trial
Dubee
Kamran
Mahevas
Yu
REMAP-CAP-HCQ
HYDRA ...
Sarhan
Sarhan
darunavir cobicistat
Jun C
doxycycline
Spoorthi
Spoorthi
Emtricitabine/tenofovir plus colchicine plus rosuvastatin
Gaitan-Duarte ...
Ensitrelvir (XOCOVA)
Mukae - Phase 2a
favipiravir
IRCT20200428047228N1 // U07
Udwadia
AVIFAVIR
Cai -FAVIPIRAVIR
Cai -FAVIPIRAVIR
Lou ...
Chang Chen et al.
NCT04310228-FAVI ...
jRCTs041190120
IRCT20150808023559N20
IRCT20150808023559N20
NCT04376814-Group A
NCT04376814-Group A
Calik
Dabbous HM
Holubar M
IRCT20151227025726N14 // U07
FACCT Trial
Udwadia
AVIFAVIR
Shenoy S
NCT04542694
Ruzhentsova T
Solaymani-Dodaran
Shinkai
Kocayigit H
favipiravir plus interferon
Khamis
hydroxychloroquine plus macrolides
Rosenberg
Carlucci
Sbidian ...
Lagier
Arshad ...
Davido
Duke university HCQ-AZI
Magagnoli ...
Huang
azithromycin plus hydroxychloroquine
ProPAC-COVID
Coalition Covid-19 Brazil I ...
ivermectin
ICON
Khan
Soto-Becerra
Spoorthi
Gonzalez ...
Glorial F
Shahbaznejad
Ahmed
Chachar
Chaccour
Espitia-Hernandez
Khan
Soto-Becerra
Spoorthi
Bukhari
Kirti
Babalola
RIVET-COV ...
Abd-Elsalam
Krolewiecki
I-TECH ...
Mayer
Camprubi
Okumuş
Galan
Galan
ivermectin plus doxycycline
Hashim A
NCT04523831 ...
lopinavir/ritonavir
RECOVERY
SOLIDARITY ...
Nojomi
Chen_lopi_rito
Ader ...
ELACOI ...
Cao
REMAP-CAP ...
Lopinavir/ritonavir plus hydroxychloroquine
REMAP-CAP ...
lopinavir/ritonavir plus interferon ß-1a
Ader ...
lopinavir/ritonavir, ribavirin and interferon beta-1b
Hung et al.
niclosamide
Abdulamir
nirmatrelvir / ritonavir (Paxlovid)
EPIC-SR
nitazoxanide
Rocco
Silva
Fontanesi
opaganib
Winthrop
oseltamivir
Chen_oseltamivir
remdesivir
NIH NIAID ACTT-1
DisCoVeRy ...
remdesevir external control
SOLIDARITY ...
Mahajan
Norwegian NOR study ...
Andreas ...
GS-US-540-5774, 10 days
GS-US-540-5774, 5 days
GS-US-540-5773 ...
CAP-China ...
sofosbuvir
Sali
Alavi-moghaddam
sofosbuvir and daclatasvir
Sadeghi
Yakoot
Mobarak S ...
Mobarak ...
Eslami
sofosbuvir and ledipasvir
Elgohary
Nourian A
tenofovir/emtricitabine
Gaitan-Duarte ...
umifenovir (arbidol)
UAIIC
Nojomi
Chen_arbidol
ELACOI ...
Yethindra
ELACOI ...
zinc
Patel
Drugs for acid related disorders
H2 blockers
famotidine
Samimagham
proton pump inhibitors (PPI)
Argenziano
Ramachandran
Zhang
miscellaneous
alpha lipoic acid
Ming Zhong
Aspirin
RECOVERY ...
aviptadil
COVID-AIV
ACTIV-3 Critical Care
camostat mesilate
Gunst JD
Cannabidiol
Crippa ...
honey
Silveira
povidone-iodine
Mohamed
pyridostigmine
Fragoso-Saavedra ...
sabizabulin
VERU-111
Oral antidiabetic drugs
dapagliflozin
DARE-19
DPP-4 inhibitor
CORONADO
Guardado-Mendoza
Rhee ...
Noh
Rhee ...
Abuhasira
Renin-angiotensin-system-acting agents
Yang
Bean
Zhang
Li
Meng
Yan et al.
angiotensin receptor blockers (ARBs)
Duarte
Nouri-Vaskeh
losartan
University of Minnesota
discontinuation of ACEI/ARB
REPLACE
Najmeddin
Lopes ...
Vitamins
vitamin C
Zhang
Jamali Moghadam Siahkali
Kumari
Vitamin D
Entrenas ...
Murai
Annweiler ...
Annweiler ...
Rastogi
Espitia-Hernandez
COVID-VIT-D
hight dose vitamin D
COVIT-TRIAL
1 studies excluded by filtering options 2
5347
Mehra, 2020
2
12
4
excluded
not a RCT
high risk of bias
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