Meta-analysis results for all treatments

Treatment relative effect with 95% CI; and degree of certainty (adaptated from GRADE). method

Treament Trials      
clinical improvementclinical worseningdeathsPCR-negative conversion
chloroquine and derivatives20 1.34 [0.96; 1.87], 4 RCTs, I2=18%
inconclusive result
0.58 [0.07; 5.05], 2 RCTs, I2=58%
inconclusive result
1.11 [0.98; 1.26], 3 RCTs, I2=0%
inconclusive result
0.83 [0.57; 1.21], 2 RCTs, I2=0%
inconclusive result
Renin-angiotensin-system-acting agents7- OBS 0.93 [0.64; 1.36], 4 studies, I2=3%
inconclusive result
OBS 0.91 [0.70; 1.17], 6 studies, I2=50%
inconclusive result
-
hydroxychloroquine plus macrolides6- 0.99 [0.57; 1.72], 1 RCT, I2=0%
inconclusive result
0.87 [0.26; 2.89], 1 RCT, I2=0%
inconclusive result
-
lopinavir/ritonavir3 1.32 [0.99; 1.78], 2 RCTs, I2=0%
inconclusive result
3.69 [0.37; 36.57], 1 RCT, I2=0%
inconclusive result
1.00 [0.80; 1.25], 2 RCTs, I2=14%
inconclusive result
1.28 [0.19; 8.76], 1 RCT, I2=0%
inconclusive result
remdesevir2 1.30 [1.12; 1.51], 2 RCTs, I2=0%
moderate degree of certainty
- 0.77 [0.54; 1.09], 2 RCTs, I2=0%
inconclusive result
-
azithromycin1-- OBS 0.56 [0.26; 1.21], 1 study, I2=0%
inconclusive result
-
favipiravir 1 1.48 [0.88; 2.48], 1 RCT, I2=0%
inconclusive result
---
interferon1 2.19 [1.03; 4.67], 1 RCT, I2=0%
unassessable degree of certainty
---
umifenovir (arbidol)1 1.48 [0.88; 2.48], 1 RCT, I2=0%
inconclusive result
0.86 [0.06; 11.36], 1 RCT, I2=0%
inconclusive result
- 2.80 [0.31; 25.53], 1 RCT, I2=0%
inconclusive result
ASC09/ritonavir0----
azvudine0----
baloxavir marboxil0----
bromhexine0----
carrimycin0----
danoprevir / ritonavir0----
darunavir cobicistat0----
darunavir/cobicistat plus chloroquine0----
fluvoxamine0----
ivermectin0----
leronlimab0----
lopinavir / ritonavir plus ribavirin0----
lopinavir/ritonavir plus chloroquine0----
lopinavir/ritonavir plus interferon ß-1a0----
lopinavir/ritonavir, ribavirin and interferon beta-1b0----
meplazumab0----
nitazoxanide0----
oseltamivir0----
oseltamivir plus chloroquin0----
ribavirin0----
ritonavir0----
tenofovir/emtricitabine0----
tenofovir/emtricitabine plus hydroxychloroquine0----
tranexamic acid0----
triazavirin0----