Study explorer (study characteristics and results) method abbreviations pdf   xlsx

display ongoing studies
Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID 19 hospitalized meta-analysis

Ranjbar
  IRCT20200204046369N1		 RCTmethylprednisolonedexamethasoneCOVID 19 hospitalizedsome concern
44/42 suggested
  • inconclusive 60 % decrease in deaths (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 64 % decrease in mechanical ventilation with a moderate degree of certainty due to some concern in risk of bias
Metcovid
  NCT04343729		 RCTmethylprednisoloneplaceboCOVID 19 hospitalizedsome concern
209/207 inconclusive
  • inconclusive 8 % decrease in deaths,death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
RECOVERY dexamethasone
  NCT04381936		 RCTdexamethasonestandard of careCOVID 19 hospitalizedsome concern
2104/4321 conclusif
  • demonstrated 17 % decrease in deaths (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 10 % increase in hospital discharge with a moderate degree of certainty due to some concern in risk of bias
  • suggested 23 % decrease in mechanical ventilation with a moderate degree of certainty due to some concern in risk of bias
in an exploratory subgroup analysis there was no benefit among patients who did not require oxygen (1.22 [0.86 to 1.75]; p=0.14)
Tang X
  NCT04273321		 RCTmethylprednisoloneplaceboCOVID 19 hospitalizedsome concern
43/43 suggested
  • inconclusive 0 % increase in clinical deterioration (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 78 % increase in viral clearance ,viral clearance (time to event analysis only) with a moderate degree of certainty due to some concern in risk of bias

COVID-19 severe or critically meta-analysis

Jamaati
  IRCT20151227025726N1		 RCTdexamethasonestandard of careCOVID-19 severe or criticallysome concern
25/25 suggested
  • inconclusive 19 % increase in deaths,death D28 (PE) with a moderate degree of certainty due to some concern in risk of bias
  • inconclusive 38 % increase in mechanical ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 3.9-fold increase in radiologic improvement (14-day) with a moderate degree of certainty due to some concern in risk of bias
Munch (COVID-STEROID)
  NCT04348305		 RCTHydrocortisoneplaceboCOVID-19 severe or criticallylow
16/14 no results
    CAPE-COVID
          NCT02517489    		 RCTHydrocortisoneplaceboCOVID-19 severe or criticallylow
    		76/73 inconclusive
    • inconclusive 29 % decrease in death or ventilation (PE) with a high degree of certainty due to low risk of bias
    CODEX (Tomazini)
          NCT04327401    		 RCTdexamethasonestandard of careCOVID-19 severe or criticallysome concern
    		151/148 inconclusive
      DEXA-COVID19
              NCT04325061      		 RCTdexamethasonestandard of careCOVID-19 severe or criticallylow
      		7/12 inconclusive
        Steroids-SARI
                  NCT04244591        		 RCTmethylprednisolonestandard of careCOVID-19 severe or criticallysome concern
        		24/23 inconclusive
          10 studies excluded by filtering options (6 RCT / 4 OBS)

          PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
          Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

           

          - About us - Contact us - Method - RSS Made with in Lyon - Credits - Privacy policy - Licence Creative Commons