baricitinib for COVID-19: living meta-analysis of clinical studies

Study explorer (study characteristics and results) method abbreviations pdf xlsx

display ongoing studies
Study	Ref.	Design	studied treatment	control treatment	patients	study risk of bias	sample sizes	Results
COVID-19 severe or critically meta-analysis
Tziolos		OBS	baricitinib	standard of care	COVID-19 severe or critically	NA	193/176	suggested	suggested 7 % decrease in death or transfer to ICU (PE) suggested 53 % decrease in deaths When we analyzed mortality separately, older age, lower PaO2/FiO2 ratio, and the use of HFNC but not remdesivir orbaricitinib were associated with reduced mortality. Baricitinib was not associated with shorter time to improvement

PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

Study explorer (study characteristics and results) method abbreviations pdf xlsx

COVID-19 severe or critically meta-analysis