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Study Ref. Design studied treatmentcontrol treatmentpatientsstudy risk of biassample sizes Results

COVID-19 severe or critically meta-analysis

Fragoso-Saavedra (PISCO)
  NCT04343963		 RCTpyridostigmineplaceboCOVID-19 severe or criticallysome concern
94/94 suggested
  • suggested 68 % decrease in death D28 with a moderate degree of certainty due to some concern in risk of bias
  • suggested 67 % decrease in deaths,deaths (time to event analysis only) with a moderate degree of certainty due to some concern in risk of bias
  • suggested 54 % decrease in death or ventilation (PE) with a moderate degree of certainty due to some concern in risk of bias

PE: primary endpoint; (a): to be demonstrated a result must be statistically significant on a primary endpoint (with multiplicity adjustment if necessary);
Study risk of bias assessed for the study primary endpoint(s) or the main endpoints in case of no formally defined primary endpoint(s).

 

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