Study | study type
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Pathology | T1 | T0 | Patients | sample sizes | ROB | Results | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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breast cancer - adjuvant breast cancer - adjuvant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
versus endocrine therapy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
palbociclib | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
PALLAS, 2022 NCT02513394 | RCT | breast cancer - adjuvant | Patients with histollogically confirmed stage II or III HR-positive BC. Before random assignment, patients had completed definitive breast surgery (and (neo)adjuvantchemotherapy and/or radiotherapy, if indicated) | 2884 / 2877 | NA | inconclusive |
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palbociclib plus endocrine therapy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
PENELOPE-B, 2021 NCT01864746 | RCT | la/mBC - HR-positive - 1st line (L1) | palbociclib plus endocrine therapy according to local standars (physician's choice) | placebo plus endocrine therapy according to local standars (physician's choice) | Women with residual invasive disease after NACT (NACT during at least 16 weeks) in the breats or in lymph nodes, ER and/or PR positive and HER2 negative tumor. | 628 / 616 | low | inconclusive |
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