published meta-analysis   sensitivity analysis   studies

complete primary vaccine series in COVID-19 prophylaxis (excluding children) - Summary of results

OutcomeTE95% CInkI2ROBPub. bias deathsdetailed resultsUKHSA report week 12 (24 March 2022), 2022 0.45 [0.19; 1.05] 0.45[0.19; 1.05]UKHSA report week 12 (24 March 2022), 202210%NAnot evaluable deaths (time to event analysis only)detailed resultsUKHSA report week 12 (24 March 2022), 2022 0.45 [0.19; 1.05] 0.45[0.19; 1.05]UKHSA report week 12 (24 March 2022), 202210%NAnot evaluable clinical deteriorationdetailed resultsLauring, 2022 0.44 [0.37; 0.52] 0.44[0.37; 0.52]Lauring, 202210%11,690NAnot evaluable confirmed COVID (any severity)detailed resultsEngland (Andrews), 2021 0.51 [0.35; 0.76] South Africa (Discovery Health, Collie), 2021 0.50 [0.38; 0.65] Southern California (Tseng) - omicron, 2022 0.70 [0.51; 0.95] Tenforde, 2022 0.18 [0.14; 0.23] Thompson -VISIOn Network (omicron), 2022 0.48 [0.42; 0.54] 0.43[0.28; 0.66]England (Andrews), 2021, South Africa (Discovery Health, Collie), 2021, Southern California (Tseng) - omicron, 2022, Tenforde, 2022, Thompson -VISIOn Network (omicron), 2022593%138,105NAnot evaluable hospitalizationdetailed resultsLauring, 2022 0.15 [0.12; 0.18] South Africa (Discovery Health, Collie), 2021 0.30 [0.24; 0.38] Thompson -VISIOn Network (omicron), 2022 0.19 [0.10; 0.36] 0.21[0.12; 0.35]Lauring, 2022, South Africa (Discovery Health, Collie), 2021, Thompson -VISIOn Network (omicron), 2022390%11,690NAnot evaluable symptomatic Covid-19detailed resultsEngland (Andrews), 2021 0.51 [0.35; 0.76] Kirsebom (UKHSA), 2022 0.76 [0.72; 0.80] South Africa (Discovery Health, Collie), 2021 0.50 [0.38; 0.65] Thompson -VISIOn Network (omicron), 2022 0.48 [0.42; 0.54] 0.56[0.41; 0.77]England (Andrews), 2021, Kirsebom (UKHSA), 2022, South Africa (Discovery Health, Collie), 2021, Thompson -VISIOn Network (omicron), 2022494%131,448NAnot evaluable0.02.01.0relative treatment effectwww.metaEvidence.org2024-06-17 18:54 +02:00

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;

pathologies: 89 - treatments: 1317 - roots T: 290