published meta-analysis   sensitivity analysis   studies

potential COVID-19 treatments in COVID-19 mild to moderate - Summary of results

OutcomeTE95% CInkI2ROBPub. bias deathsdetailed resultsHung et al., 2020 0.47 [0.01; 24.30] Solaymani-Dodaran, 2021 1.22 [0.66; 2.26] 1.20[0.65; 2.19]Hung et al., 2020, Solaymani-Dodaran, 202120%500moderatenot evaluable clinical deteriorationdetailed resultsELACOI (lopinavir/ritonavir), 2020 3.69 [0.37; 36.57] 3.69[0.37; 36.57]ELACOI (lopinavir/ritonavir), 202010%28NAnot evaluable clinical improvementdetailed resultsHung et al., 2020 3.92 [1.66; 9.24] 3.92[1.66; 9.24]Hung et al., 202010%127NAnot evaluable clinical improvement (time to event analysis only)detailed resultsHung et al., 2020 3.92 [1.66; 9.24] Solaymani-Dodaran, 2021 0.94 [0.75; 1.17] 1.80[0.45; 7.27]Hung et al., 2020, Solaymani-Dodaran, 2021290%507moderatenot evaluable mechanical ventilationdetailed resultsSolaymani-Dodaran, 2021 1.62 [0.85; 3.08] 1.62[0.85; 3.08]Solaymani-Dodaran, 202110%373NAnot evaluable radiologic improvement (14-day)detailed resultsELACOI (lopinavir/ritonavir), 2020 0.48 [0.02; 11.28] 0.48[0.02; 11.28]ELACOI (lopinavir/ritonavir), 202010%25NAnot evaluable radiologic improvement (7-day)detailed resultsELACOI (lopinavir/ritonavir), 2020 0.10 [0.00; 2.09] 0.10[0.00; 2.09]ELACOI (lopinavir/ritonavir), 202010%25NAnot evaluable viral clearance detailed resultsELACOI (lopinavir/ritonavir), 2020 1.28 [0.19; 8.76] Hung et al., 2020 4.37 [1.86; 10.25] 3.24[1.15; 9.10]ELACOI (lopinavir/ritonavir), 2020, Hung et al., 2020224%155moderatenot evaluable viral clearance (time to event analysis only)detailed resultsHung et al., 2020 4.37 [1.86; 10.25] 4.37[1.86; 10.25]Hung et al., 202010%127NAnot evaluable viral clearance by day 14detailed resultsELACOI (lopinavir/ritonavir), 2020 1.28 [0.19; 8.76] ELACOI (Lopinavir/ritonavir), 2020 1.84 [0.40; 8.38] 1.60[0.49; 5.27]ELACOI (lopinavir/ritonavir), 2020, ELACOI (Lopinavir/ritonavir), 202020%97moderatenot evaluable viral clearance by day 7detailed resultsELACOI (lopinavir/ritonavir), 2020 0.30 [0.05; 1.91] ELACOI (Lopinavir/ritonavir), 2020 1.08 [0.41; 2.89] 0.73[0.23; 2.33]ELACOI (lopinavir/ritonavir), 2020, ELACOI (Lopinavir/ritonavir), 2020231%97moderatenot evaluable ICU admissiondetailed resultsSolaymani-Dodaran, 2021 1.23 [0.70; 2.18] 1.23[0.70; 2.18]Solaymani-Dodaran, 202110%373NAnot evaluable severe COVID-19 occurrencedetailed resultsELACOI (Lopinavir/ritonavir), 2020 0.30 [0.07; 1.27] 0.30[0.07; 1.27]ELACOI (Lopinavir/ritonavir), 202010%69NAnot evaluable serious adverse eventsdetailed resultsHung et al., 2020 0.23 [0.01; 7.12] 0.23[0.01; 7.12]Hung et al., 202010%127NAnot evaluable0.010.01.0relative treatment effectwww.metaEvidence.org2024-10-31 23:50 +01:00

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;

pathologies: 90 - treatments: 290,547,608,830,831,829,901,680,595,828,681,1209,833,629,689,543,617,625,859,511,960,546,564,944,682,1266,943,894,560,1102,598,563,668,753,752,836,639,541,534,581,615,679,522,582,666,1149,1150,737,544,733,597,524,611,538,957,958,521,566,517,881,904,882,897,896,899,1235,898,687,740,883,947,536,591,729,887,742,878,975,570,771,888,1141,690,880,1255,567,596,1437,600,652,557,635,1236,553,628,646,645,607,395,920,1438,927,932,931,1263,599,614,942,1436,928,923,535,1046,727,818,606,954,964,962,963,1045,638,677,627,533,526,616,926,1246,726,580,568,527,588,539,585,691,1210,525,843,827,1047,1048,819,545,1253,519,619,537,514,688,529,508,656,657,832,530,512,515,754,1142,1419,513,884,632,559,889,956,684,886,631,574,509,542,1145,555,554,941,961,1250,633,676,518,532,510,528,520,955,815,893,623,622,630,593,569,516,814,649,650,589,651,968,1245,610,751,747,695,548,970,594,565,879,1257,571,626,697,572,1234,586,573,540,592,930,949,838,698,934,735,929,948,946,945,587,655,1146,531,933,613,919,725,678,921,621,959,748,1348,1256,924,1243,925,658,699,612,552,590,891,605,892,722,618,609,551,834,763,922,935,620,1317,1265,824,766,857,1291,1088,1331,1330,1329,1344,1328,1327,979,822,762,805,950,757,761,806,758,826,755,821,1288,1287,1286,760,1284,802,765,1285,759,823,804,1264,764,858,835,1262,1290,1316,1341,1342,1343,825,803,1244,523,885,734,1439 - roots T: 290