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ivermectin - versus standard of care - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 1.16 [0.09, 15.55]< 10%2 studies (2/-)45.5 %some concernnot evaluable moderatecrucial-
deaths 0.46 [0.15, 1.43]< 10%4 studies (3/1)91.0 %moderatenot evaluable moderatecrucial-
clinical deterioration 0.44 [0.24, 0.78]< 10%2 studies (2/-)99.7 %some concernnot evaluable moderateimportant-
clinical improvement 1.57 [0.96, 2.57]> 10%4 studies (2/2)96.4 %moderatenot evaluable moderateimportant-
clinical improvement (7-day) 1.74 [1.18, 2.54]> 10%3 studies (2/1)99.8 %moderatenot evaluable moderateimportant-
clinical improvement (time to event analysis only) 1.89 [1.06, 3.38]> 10%1 study (1/-)98.4 %NAnot evaluable important-
mechanical ventilation 2.24 [0.19, 25.88]< 10%1 study (1/-)26.0 %NAnot evaluable important-
viral clearance 15.09 [0.01, 17724.71]> 191%2 studies (1/1)76.1 %NAnot evaluable important-
viral clearance by day 14 0.91 [0.02, 46.94]> 10%1 study (1/-)48.2 %NAnot evaluable important-
viral clearance by day 7 11.56 [3.53, 37.91]> 10%1 study (1/-)100.0 %NAnot evaluable important-

safety endpoints 00

serious adverse events 2.14 [0.21, 21.56]< 10%2 studies (2/-)26.0 %some concernnot evaluable moderateimportant-
adverse events 3.80 [0.36, 40.08]< 159%2 studies (2/-)13.5 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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