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anti-interleukin-6 - versus standard of care - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.74 [0.53, 1.04]< 18%12 studies (12/-)96.0 %some concernlow moderatecrucial-
deaths 0.82 [0.74, 0.90]< 10%19 studies (19/-)100.0 %some concernlow moderatecrucial-
deaths (time to event analysis only) 0.68 [0.41, 1.13]< 10%2 studies (2/-)93.2 %some concernnot evaluable moderatecrucial-
clinical deterioration 0.85 [0.59, 1.22]< 10%4 studies (4/-)81.3 %some concernnot evaluable moderateimportant-
clinical improvement 1.68 [1.34, 2.11]> 10%3 studies (3/-)100.0 %some concernnot evaluable moderateimportant-
clinical improvement (14-day) 1.86 [1.20, 2.87]> 10%1 study (1/-)99.7 %NAnot evaluable important-
death or ventilation 0.84 [0.69, 1.01]< 118%5 studies (5/-)96.8 %some concernnot evaluable moderateimportant-
mechanical ventilation 0.97 [0.58, 1.62]< 116%4 studies (4/-)55.1 %some concernnot evaluable moderateimportant-
ICU admission 1.17 [0.77, 1.77]< 10%3 studies (3/-)23.6 %some concernnot evaluable moderatenon important-
recovery 0.64 [0.14, 2.92]> 10%1 study (1/-)28.3 %NAnot evaluable non important-

safety endpoints 00

serious adverse events 1.27 [0.70, 2.32]< 10%4 studies (4/-)21.9 %some concernnot evaluable moderateimportant-
adverse events 2.47 [1.00, 6.10]< 172%3 studies (3/-)2.5 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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