Table Graph
   

tocilizumab - versus standard of care - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.78 [0.53, 1.14]< 115%11 studies (11/-)90.0 %some concernlow moderatecrucial-
deaths 0.82 [0.75, 0.91]< 10%17 studies (17/-)100.0 %some concernlow moderatecrucial-
deaths (time to event analysis only) 0.68 [0.41, 1.13]< 10%2 studies (2/-)93.2 %some concernnot evaluable moderatecrucial-
clinical deterioration 0.80 [0.53, 1.22]< 10%3 studies (3/-)84.8 %some concernnot evaluable moderateimportant-
clinical improvement 1.65 [1.27, 2.16]> 10%2 studies (2/-)100.0 %some concernnot evaluable moderateimportant-
death or ventilation 0.81 [0.64, 1.03]< 129%4 studies (4/-)95.8 %some concernnot evaluable moderateimportant-
mechanical ventilation 0.97 [0.58, 1.62]< 116%4 studies (4/-)55.1 %some concernnot evaluable moderateimportant-
ICU admission 1.17 [0.77, 1.77]< 10%3 studies (3/-)23.6 %some concernnot evaluable moderatenon important-
recovery 0.64 [0.14, 2.92]> 10%1 study (1/-)28.3 %NAnot evaluable non important-

safety endpoints 00

serious adverse events 1.27 [0.70, 2.32]< 10%4 studies (4/-)21.9 %some concernnot evaluable moderateimportant-
adverse events 2.47 [1.00, 6.10]< 172%3 studies (3/-)2.5 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

- About us - Contact us - Method - RSS Made with in Lyon - Credits - Privacy policy - Licence Creative Commons