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colchicine - versus control - for COVID-19 mild to moderate pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.24 [0.01, 5.41]< 10%1 study (1/-)81.3 %NAnot evaluable crucial-
deaths 0.42 [0.04, 4.91]< 10%2 studies (2/-)75.3 %some concernnot evaluable moderatecrucial-
clinical deterioration 0.38 [0.09, 1.58]< 10%1 study (1/-)90.7 %NAnot evaluable important-
mechanical ventilation 0.24 [0.01, 5.41]< 10%1 study (1/-)81.3 %NAnot evaluable important-
ICU admission 0.47 [0.08, 2.69]< 10%1 study (1/-)80.1 %NAnot evaluable non important-

safety endpoints 00

serious adverse events 0.24 [0.01, 5.41]< 10%1 study (1/-)81.3 %NAnot evaluable important-
adverse events 1.72 [0.73, 4.08]< 10%1 study (1/-)10.9 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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