Outcome |
Relative effect 95%CI |
LoD |
Trt. better when |
|
I2 |
k (RCT/OBS)
|
Bayesian probability
|
Overall ROB
|
Publication bias |
Degree of certainty |
Endpoint importance |
Published MA |
efficacy endpoints 00 |
death D28 | 0.72 [0.57, 0.90] | | < 1 | | 0% | 15 studies (15/-) | 99.8 % | some concern | low | moderate | crucial | - |
death or transfer to ICU | 0.89 [0.59, 1.34] | | < 1 | | 46% | 2 studies (2/-) | 71.8 % | high | not evaluable | low | crucial | - |
deaths | 0.83 [0.72, 0.97] | | < 1 | | 5% | 47 studies (43/4) | 99.2 % | moderate | critical | moderate | crucial | - |
deaths (time to event analysis only) | 0.51 [0.24, 1.06] | | < 1 | | 40% | 5 studies (4/1) | 96.4 % | moderate | not evaluable | moderate | crucial | - |
clinical deterioration | 0.71 [0.52, 0.98] | | < 1 | | 63% | 18 studies (18/-) | 98.2 % | some concern | low | moderate | important | - |
clinical improvement | 1.23 [1.01, 1.49] | | > 1 | | 59% | 18 studies (17/1) | 98.2 % | moderate | low | moderate | important | - |
clinical improvement (14-day) | 1.22 [1.00, 1.49] | | > 1 | | 32% | 10 studies (10/-) | 97.6 % | some concern | low | moderate | important | - |
clinical improvement (21-day) | 2.09 [0.04, 119.96] | | > 1 | | 0% | 1 study (1/-) | 63.7 % | NA | not evaluable | | important | - |
clinical improvement (28-day) | 1.34 [1.10, 1.62] | | > 1 | | 46% | 5 studies (5/-) | 99.8 % | some concern | serious | moderate | important | - |
clinical improvement (7-day) | 1.25 [1.02, 1.55] | | > 1 | | 64% | 11 studies (11/-) | 98.2 % | some concern | critical | moderate | important | - |
clinical improvement (time to event analysis only) | 1.17 [1.00, 1.37] | | > 1 | | 64% | 13 studies (12/1) | 97.2 % | moderate | critical | moderate | important | - |
death or ventilation | 0.75 [0.63, 0.88] | | < 1 | | 0% | 5 studies (5/-) | 100.0 % | some concern | not evaluable | moderate | important | - |
hospital discharge | 1.91 [1.17, 3.12] | | > 1 | | 89% | 8 studies (7/1) | 99.5 % | moderate | serious | moderate | important | - |
hospitalization | 0.46 [0.06, 3.45] | | < 1 | | 28% | 2 studies (2/-) | 77.4 % | low | not evaluable | high | important | - |
mechanical ventilation | 1.04 [0.73, 1.47] | | < 1 | | 40% | 17 studies (16/1) | 41.3 % | moderate | critical | moderate | important | - |
mechanical ventilation (time to event analysis only) | 0.06 [0.01, 0.83] | | < 1 | | 0% | 1 study (1/-) | 98.2 % | NA | not evaluable | | important | - |
radiologic improvement (14-day) | 1.82 [0.95, 3.51] | | > 1 | | 39% | 4 studies (4/-) | 96.4 % | some concern | not evaluable | moderate | important | - |
radiologic improvement (7-day) | 0.98 [0.09, 10.24] | | > 1 | | 72% | 4 studies (4/-) | 49.3 % | some concern | not evaluable | moderate | important | - |
viral clearance | 1.56 [1.19, 2.06] | | > 1 | | 72% | 21 studies (20/1) | 99.9 % | moderate | critical | moderate | important | - |
viral clearance (time to event analysis only) | 1.25 [0.91, 1.72] | | > 1 | | 71% | 8 studies (7/1) | 91.6 % | moderate | serious | moderate | important | - |
viral clearance by day 14 | 1.04 [0.23, 4.74] | | > 1 | | 93% | 10 studies (10/-) | 51.9 % | some concern | low | moderate | important | - |
viral clearance by day 7 | 1.33 [1.05, 1.68] | | > 1 | | 67% | 15 studies (15/-) | 99.1 % | some concern | critical | moderate | important | - |
ICU admission | 0.85 [0.56, 1.28] | | < 1 | | 42% | 10 studies (9/1) | 78.2 % | moderate | low | moderate | non important | - |
recovery | 1.01 [0.82, 1.25] | | > 1 | | 56% | 4 studies (4/-) | 54.1 % | some concern | not evaluable | moderate | non important | - |
severe COVID-19 occurrence | 0.30 [0.07, 1.27] | | < 1 | | 0% | 1 study (1/-) | 94.9 % | NA | not evaluable | | non important | - |
safety endpoints 00 |
serious adverse events | 0.74 [0.53, 1.02] | | < 1 | | 0% | 17 studies (17/-) | 96.6 % | some concern | low | moderate | important | - |
acute kidney injury | 1.18 [0.44, 3.18] | | < 1 | | 0% | 1 study (1/-) | 37.2 % | NA | not evaluable | | non important | - |
adverse events | 1.85 [1.37, 2.48] | | < 1 | | 61% | 22 studies (22/-) | 0.0 % | some concern | low | moderate | non important | - |
arrhythmia | 2.24 [0.23, 21.69] | | < 1 | | 0% | 1 study (1/-) | 24.5 % | NA | not evaluable | | non important | - |
elevated liver enzymes | 3.48 [1.40, 8.64] | | < 1 | | 0% | 1 study (1/-) | 0.4 % | NA | not evaluable | | non important | - |
long QT | 9.79 [1.27, 75.50] | | < 1 | | 0% | 1 study (1/-) | 1.5 % | NA | not evaluable | | non important | - |
Major bleeding | 1.80 [0.88, 3.67] | | < 1 | | 0% | 1 study (1/-) | 5.3 % | NA | not evaluable | | non important | - |
renal impairment | 1.35 [0.47, 3.86] | | < 1 | | 0% | 1 study (1/-) | 28.8 % | NA | not evaluable | | non important | - |
serious adverse events (SAE), any | 0.50 [0.32, 0.79] | | < 1 | | 0% | 1 study (1/-) | 99.9 % | NA | not evaluable | | non important | - |
AE of interest endpoints 00 |
Thromboembolic events | 0.89 [0.31, 2.55] | | < 1 | | 0% | 1 study (1/-) | 58.6 % | NA | not evaluable | | non important | - |