All patients
Age < 65y (younger) Age > 65y ECOG 0 ECOG 1 Gender, female Gender, male PD-L1 < 1% PD-L1 > 1% previous nephrectomy (no) previous nephrectomy (yes) Risk favorable (IMDC) Risk intermediate (IMDC) Risk poor (IMDC) smoker (current or former) smoker (never)
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
metastatic/advanced RCC (mRCC) - 1st line (L1), avelumab based treatment vs. VEGF(R) inhibitor, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results JAVELIN Renal 101 (all population), 2019 0.80 [0.62; 1.03]
JAVELIN Renal 101( PDL1>1%), 2019 0.69 [0.58; 0.83]
0.73 [0.63 ; 0.84 ] JAVELIN Renal 101 (all population), 2019, JAVELIN Renal 101( PDL1>1%), 2019 2 0% 1,446 moderate not evaluable PFS (extension)detailed results JAVELIN Renal 101 (all population), 2019 0.69 [0.58; 0.83]
JAVELIN Renal 101( PDL1>1%), 2019 0.62 [0.49; 0.78]
0.66 [0.57 ; 0.76 ] JAVELIN Renal 101 (all population), 2019, JAVELIN Renal 101( PDL1>1%), 2019 2 0% 1,446 moderate not evaluable progression or deaths (PFS)detailed results JAVELIN Renal 101 (all population), 2019 0.69 [0.56; 0.85]
JAVELIN Renal 101( PDL1>1%), 2019 0.61 [0.47; 0.79]
0.66 [0.56 ; 0.77 ] JAVELIN Renal 101 (all population), 2019, JAVELIN Renal 101( PDL1>1%), 2019 2 0% 1,446 moderate not evaluable objective responses (ORR)detailed results JAVELIN Renal 101 (all population), 2019 2.95 [2.23; 3.90]
JAVELIN Renal 101( PDL1>1%), 2019 3.39 [2.38; 4.82]
3.11 [2.50 ; 3.88 ] JAVELIN Renal 101 (all population), 2019, JAVELIN Renal 101( PDL1>1%), 2019 2 0% 1,446 moderate not evaluable AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.98 [0.73; 1.32]
0.98 [0.73 ; 1.32 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable AE leading to death (grade 5)detailed results JAVELIN Renal 101 (all population), 2019 3.05 [0.32; 29.42]
3.05 [0.32 ; 29.42 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable AE leading to treatment discontinuation (any grade)detailed results JAVELIN Renal 101 (all population), 2019 0.53 [0.34; 0.83]
0.53 [0.34 ; 0.83 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable TRAE (any grade)detailed results JAVELIN Renal 101 (all population), 2019 0.78 [0.40; 1.53]
0.78 [0.40 ; 1.53 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.06 [0.81; 1.38]
1.06 [0.81 ; 1.38 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Anaemia TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.04 [0.01; 0.33]
0.04 [0.01 ; 0.33 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Arthralgia TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 2.03 [0.07; 60.53]
2.03 [0.07 ; 60.53 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Asthenia TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.63 [0.20; 1.93]
0.63 [0.20 ; 1.93 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Chills TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 2.03 [0.07; 60.53]
2.03 [0.07 ; 60.53 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Decreased appetite TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.78 [0.52; 6.13]
1.78 [0.52 ; 6.13 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Diarrhoea TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 2.08 [0.99; 4.34]
2.08 [0.99 ; 4.34 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Dysgeusia TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.01 [0.02; 51.10]
1.01 [0.02 ; 51.10 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Dyspepsia TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.01 [0.02; 51.10]
1.01 [0.02 ; 51.10 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Dysphonia TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 4.06 [0.18; 90.30]
4.06 [0.18 ; 90.30 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Dyspnoea TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 6.14 [0.74; 51.22]
6.14 [0.74 ; 51.22 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Fatigue TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.82 [0.39; 1.72]
0.82 [0.39 ; 1.72 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Hypertension TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.79 [1.28; 2.52]
1.79 [1.28 ; 2.52 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Hypothyroidism TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.01 [0.06; 16.22]
1.01 [0.06 ; 16.22 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Increase AST TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 2.05 [0.76; 5.52]
2.05 [0.76 ; 5.52 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Increased ALT TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 2.43 [1.10; 5.37]
2.43 [1.10 ; 5.37 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Infusion-related reactions TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 14.38 [0.81; 254.14]
14.38 [0.81 ; 254.14 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Mucosal inflammation TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.27 [0.34; 4.75]
1.27 [0.34 ; 4.75 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Nausea TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.60 [0.14; 2.54]
0.60 [0.14 ; 2.54 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Neutropenia TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.03 [0.00; 0.20]
0.03 [0.00 ; 0.20 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Palmar-plantar erythrodysaesthesia syndrome TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.35 [0.73; 2.49]
1.35 [0.73 ; 2.49 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Pruritus TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.01 [0.02; 51.10]
1.01 [0.02 ; 51.10 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Rash TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.01 [0.14; 7.21]
1.01 [0.14 ; 7.21 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Stomatitis TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 2.04 [0.61; 6.83]
2.04 [0.61 ; 6.83 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Thrombocytopenia TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.04 [0.01; 0.30]
0.04 [0.01 ; 0.30 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Vomiting TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.14 [0.02; 1.16]
0.14 [0.02 ; 1.16 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Weight decreased TRAE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 7.18 [0.88; 58.61]
7.18 [0.88 ; 58.61 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Abdominal pain AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.63 [0.20; 1.93]
0.63 [0.20 ; 1.93 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Anaemia AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.18 [0.08; 0.42]
0.18 [0.08 ; 0.42 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Arthralgia AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 2.03 [0.37; 11.16]
2.03 [0.37 ; 11.16 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Asthenia AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.85 [0.38; 1.92]
0.85 [0.38 ; 1.92 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Back pain AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.25 [0.05; 1.18]
0.25 [0.05 ; 1.18 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Chills AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 2.03 [0.07; 60.53]
2.03 [0.07 ; 60.53 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Constipation AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.01 [0.02; 51.10]
1.01 [0.02 ; 51.10 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Cough AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 2.03 [0.07; 60.53]
2.03 [0.07 ; 60.53 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Decreased appetite AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 2.30 [0.70; 7.54]
2.30 [0.70 ; 7.54 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Diarrhoea AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 2.55 [1.28; 5.06]
2.55 [1.28 ; 5.06 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Dizziness AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.67 [0.11; 4.05]
0.67 [0.11 ; 4.05 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Dry skin AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.01 [0.02; 51.10]
1.01 [0.02 ; 51.10 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Dysgeusia AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.01 [0.02; 51.10]
1.01 [0.02 ; 51.10 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Dyspepsia AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.01 [0.02; 51.10]
1.01 [0.02 ; 51.10 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Dysphonia AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 4.06 [0.18; 90.30]
4.06 [0.18 ; 90.30 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Dyspnoea AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.91 [0.75; 4.82]
1.91 [0.75 ; 4.82 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Epistaxis AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.01 [0.02; 51.10]
1.01 [0.02 ; 51.10 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Fatigue AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.95 [0.46; 1.94]
0.95 [0.46 ; 1.94 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Headache AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.01 [0.06; 16.22]
1.01 [0.06 ; 16.22 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Hypertension AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.67 [1.20; 2.32]
1.67 [1.20 ; 2.32 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Hypothyroidism AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.01 [0.06; 16.22]
1.01 [0.06 ; 16.22 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Increase AST AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.95 [0.86; 4.42]
1.95 [0.86 ; 4.42 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Increased ALT AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 2.48 [1.21; 5.08]
2.48 [1.21 ; 5.08 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Mucosal inflammation AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.01 [0.29; 3.52]
1.01 [0.29 ; 3.52 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Nausea AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.87 [0.29; 2.60]
0.87 [0.29 ; 2.60 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Neutropenia AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.03 [0.00; 0.20]
0.03 [0.00 ; 0.20 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Oropharyngeal pain AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.01 [0.02; 51.10]
1.01 [0.02 ; 51.10 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Palmar–plantar erythrodysesthesia syndrome AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.35 [0.73; 2.49]
1.35 [0.73 ; 2.49 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Peripheral oedema AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 2.03 [0.18; 22.45]
2.03 [0.18 ; 22.45 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Pruritus AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.01 [0.02; 51.10]
1.01 [0.02 ; 51.10 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Pyrexia AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.51 [0.02; 15.10]
0.51 [0.02 ; 15.10 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Rash AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 1.01 [0.14; 7.21]
1.01 [0.14 ; 7.21 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Stomatitis AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 2.04 [0.61; 6.83]
2.04 [0.61 ; 6.83 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Thrombocytopenia AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.04 [0.00; 0.26]
0.04 [0.00 ; 0.26 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Vomiting AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 0.57 [0.17; 1.98]
0.57 [0.17 ; 1.98 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable Weight decreased AE (grade 3-4)detailed results JAVELIN Renal 101 (all population), 2019 3.09 [0.99; 9.66]
3.09 [0.99 ; 9.66 ] JAVELIN Renal 101 (all population), 2019 1 0% 873 NA not evaluable 0.0 20.0 1.0 relative treatment effect www.metaEvidence.org 2024-10-06 15:41 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 79,178,152
- treatments: 852,417,603,1051,876